Skip to content
Use your HSA or FSA funds

Gene

AKT2

AKT serine/threonine kinase 2

Summary

Cytogenetic location
19q13.2
Coordinates
Chromosome 19: 40,230,317–40,285,345 (GRCh38)
Exons
14 exons across 55 kb
Protein
481 amino acids
Inheritance
Autosomal dominant
Also known as
PKBβ
MANE Select transcript
ENST00000392038.7NM_001626.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Diabetes Mellitus

    • A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems

  • Lipodystrophy

    • Familial Partial Lipodystrophy

      Includes the LMNA (Dunnigan), PPARG, PLIN1, LIPE, AKT2, CAV1 and PLAAT3 forms, which cause loss of fat from the limbs and buttocks with insulin resistance, diabetes, high triglycerides and fatty liver.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing allows early screening and treatment of diabetes, triglycerides and liver disease, and in selected cases metreleptin.

  • Severe Inherited Insulin Resistance

    • Hypoinsulinaemic hypoglycaemia with body hemihypertrophyAutosomal dominant

      Low blood sugar with low insulin and uneven body growth, caused by activating AKT2 variants.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How AKT2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where AKT2 sits. AKT2 and 27 genes near it on chromosome 19, from 39,757,831 to 40,757,830.Chromosome 1919q13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4339.8 Mb40 Mb40.2 Mb40.4 Mb40.6 MbLEUTX: 39,776,595–39,786,291, forward strandLEUTXDYRK1B: 39,825,350–39,834,201, reverse strandDYRK1B: 39,830,482–39,831,956, reverse strandFBL: 39,834,443–39,846,440, reverse strandFBLFCGBP: 39,863,323–39,934,634, reverse strandFCGBPPSMC4: 39,970,990–39,982,814, forward strandPSMC4ZNF546: 39,984,134–40,021,038, forward strandZNF546ZNF780B: 40,023,079–40,056,305, reverse strandZNF780BZNF780A: 40,069,152–40,091,140, reverse strandZNF780AMAP3K10: 40,191,412–40,215,579, forward strandMAP3K10TTC9B: 40,216,058–40,218,521, reverse strandTTC9BCCNP: 40,222,208–40,226,697, reverse strandCCNPAKT2: 40,230,317–40,285,345, reverse strandAKT2C19orf47: 40,294,427–40,348,547, reverse strandC19orf47PLD3: 40,348,453–40,389,472, forward strandPLD3HIPK4: 40,379,271–40,390,181, reverse strandHIPK4PRX: 40,393,764–40,415,070, reverse strandPRXSERTAD1: 40,421,589–40,426,001, reverse strandSERTAD1SERTAD3: 40,440,642–40,445,114, reverse strandSERTAD3BLVRB: 40,446,758–40,465,826, reverse strandBLVRBSPTBN4: 40,466,241–40,576,464, forward strandSPTBN4SHKBP1: 40,576,844–40,591,399, forward strandSHKBP1LTBP4: 40,592,883–40,629,821, forward strandLTBP4NUMBL: 40,665,905–40,690,972, reverse strandNUMBLCOQ8B: 40,691,514–40,725,784, reverse strandCOQ8BITPKC: 40,716,964–40,740,860, forward strandITPKCACTMAP: 40,740,856–40,751,813, reverse strandACTMAPSNRPA: 40,750,585–40,765,393, forward strandSNRPADiagram of AKT2: 14 exons on the reverse strand of chromosome 19Exon 3: 1 known disease-causing siteExon 14: 40,230,317–40,233,951, 3,635 basesExon 13: 40,235,045–40,235,147, 103 basesExon 12: 40,235,263–40,235,350, 88 basesExon 11: 40,235,890–40,236,104, 215 basesExon 10: 40,236,257–40,236,385, 129 basesExon 9: 40,237,969–40,238,091, 123 basesExon 8: 40,238,905–40,238,973, 69 basesExon 7: 40,240,045–40,240,110, 66 basesExon 6: 40,241,938–40,242,069, 132 basesExon 5: 40,242,534–40,242,687, 154 basesExon 4: 40,255,158–40,255,269, 112 basesExon 3: 40,256,926–40,257,054, 129 basesExon 2: 40,265,222–40,265,351, 130 basesExon 1: 40,285,181–40,285,345, 165 bases1410515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.3 kb of the gene's 55 kb; 1,446 of those bases code for the protein.

How a genome test reads AKT2

1

position in AKT2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 55 kb of AKT2, introns included, not only the 5.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AKT2 gene: AKT serine/threonine kinase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/akt2

Vancouver

Dante Labs. AKT2 gene: AKT serine/threonine kinase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/akt2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test