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Gene

DNAH9

dynein axonemal heavy chain 9

Summary

Cytogenetic location
17p12
Coordinates
Chromosome 17: 11,598,470–11,969,748 (GRCh38)
Exons
69 exons across 371.3 kb
Protein
4,486 amino acids
Inheritance
Autosomal recessive
Also known as
Dnahc9, KIAA0357, HL20, HL-20, DNAL1, DYH9
Previous symbols
DNAH17L
MANE Select transcript
ENST00000262442.9NM_001372.4
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Ciliary Dyskinesia

    • Autosomal recessive

      A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How DNAH9 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where DNAH9 sits. DNAH9 and 3 genes near it on chromosome 17, from 11,227,191 to 12,341,027.Chromosome 1717p12p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.311.4 Mb11.6 Mb11.8 Mb12 Mb12.2 MbSHISA6: 11,240,538–11,564,063, forward strandSHISA6DNAH9: 11,598,470–11,969,748, forward strandDNAH9ZNF18: 11,956,202–11,997,494, reverse strandZNF18MAP2K4: 12,020,808–12,143,830, forward strandMAP2K4Diagram of DNAH9: 69 exons on the forward strand of chromosome 17Exon 1: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 17: 2 known disease-causing sitesExon 19: 1 known disease-causing siteExon 20: 4 known disease-causing sitesExon 23: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 28: 1 known disease-causing siteExon 31: 1 known disease-causing siteExon 32: 1 known disease-causing siteExon 33: 1 known disease-causing siteExon 43: 1 known disease-causing siteExon 46: 1 known disease-causing siteExon 47: 1 known disease-causing siteExon 53: 1 known disease-causing siteExon 58: 1 known disease-causing siteExon 60: 2 known disease-causing sitesExon 65: 3 known disease-causing sitesExon 68: 1 known disease-causing siteExon 1: 11,598,470–11,598,915, 446 basesExon 2: 11,608,129–11,608,325, 197 basesExon 3: 11,610,396–11,610,554, 159 basesExon 4: 11,611,650–11,611,780, 131 basesExon 5: 11,617,411–11,617,622, 212 basesExon 6: 11,619,548–11,619,781, 234 basesExon 7: 11,629,417–11,629,584, 168 basesExon 8: 11,632,587–11,632,703, 117 basesExon 9: 11,636,634–11,636,784, 151 basesExon 10: 11,640,270–11,640,384, 115 basesExon 11: 11,644,631–11,644,699, 69 basesExon 12: 11,647,072–11,647,198, 127 basesExon 13: 11,651,069–11,651,324, 256 basesExon 14: 11,652,761–11,653,002, 242 basesExon 15: 11,664,833–11,664,968, 136 basesExon 16: 11,669,064–11,669,260, 197 basesExon 17: 11,669,370–11,669,794, 425 basesExon 18: 11,679,757–11,679,979, 223 basesExon 19: 11,680,723–11,680,889, 167 basesExon 20: 11,689,566–11,690,436, 871 basesExon 21: 11,693,868–11,693,998, 131 basesExon 22: 11,694,321–11,694,447, 127 basesExon 23: 11,699,731–11,699,883, 153 basesExon 24: 11,701,122–11,701,247, 126 basesExon 25: 11,704,203–11,704,442, 240 basesExon 26: 11,705,025–11,705,185, 161 basesExon 27: 11,719,334–11,719,490, 157 basesExon 28: 11,727,818–11,727,922, 105 basesExon 29: 11,738,880–11,739,037, 158 basesExon 30: 11,742,175–11,742,313, 139 basesExon 31: 11,744,797–11,745,084, 288 basesExon 32: 11,747,556–11,747,766, 211 basesExon 33: 11,752,833–11,752,960, 128 basesExon 34: 11,756,568–11,756,676, 109 basesExon 35: 11,757,545–11,757,692, 148 basesExon 36: 11,763,440–11,763,614, 175 basesExon 37: 11,768,453–11,768,626, 174 basesExon 38: 11,769,122–11,769,329, 208 basesExon 39: 11,781,009–11,781,174, 166 basesExon 40: 11,783,646–11,783,748, 103 basesExon 41: 11,784,300–11,784,539, 240 basesExon 42: 11,793,503–11,793,664, 162 basesExon 43: 11,797,597–11,797,793, 197 basesExon 44: 11,807,732–11,807,894, 163 basesExon 45: 11,810,246–11,810,369, 124 basesExon 46: 11,821,920–11,822,062, 143 basesExon 47: 11,822,438–11,822,599, 162 basesExon 48: 11,822,801–11,823,034, 234 basesExon 49: 11,834,638–11,834,898, 261 basesExon 50: 11,854,003–11,854,428, 426 basesExon 51: 11,869,134–11,869,253, 120 basesExon 52: 11,871,598–11,871,786, 189 basesExon 53: 11,874,949–11,875,184, 236 basesExon 54: 11,880,078–11,880,200, 123 basesExon 55: 11,881,209–11,881,413, 205 basesExon 56: 11,883,586–11,883,750, 165 basesExon 57: 11,886,825–11,886,965, 141 basesExon 58: 11,891,777–11,891,947, 171 basesExon 59: 11,894,374–11,894,496, 123 basesExon 60: 11,902,719–11,902,912, 194 basesExon 61: 11,905,661–11,905,809, 149 basesExon 62: 11,923,814–11,923,941, 128 basesExon 63: 11,929,866–11,930,093, 228 basesExon 64: 11,932,014–11,932,205, 192 basesExon 65: 11,933,880–11,934,071, 192 basesExon 66: 11,937,352–11,937,522, 171 basesExon 67: 11,942,303–11,942,485, 183 basesExon 68: 11,961,867–11,962,256, 390 basesExon 69: 11,969,300–11,969,748, 449 bases15101520253035404550556065695′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 13.7 kb of the gene's 371.3 kb; 13,461 of those bases code for the protein.

How a genome test reads DNAH9

39

positions in DNAH9 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 371.3 kb of DNAH9, introns included, not only the 13.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNAH9 gene: dynein axonemal heavy chain 9. Retrieved 17 October 2026, from https://dantelabs.com/genes/dnah9

Vancouver

Dante Labs. DNAH9 gene: dynein axonemal heavy chain 9 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dnah9

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