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Gene

LHB

luteinizing hormone subunit beta

Summary

Cytogenetic location
19q13.33
Coordinates
Chromosome 19: 49,015,980–49,017,091 (GRCh38)
Exons
3 exons across 1.1 kb
Protein
141 amino acids
Also known as
LSH-B, CGB4, hLHB
MANE Select transcript
ENST00000649238.3NM_000894.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hypogonadotropic Hypogonadism

    • Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.

      • 2 GenCC submitters rate it definitive or strong

How LHB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 19, with a bracket where LHB sits. LHB and 57 genes near it on chromosome 19, from 48,516,536 to 49,516,535.Chromosome 1919q13.33p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4348.6 Mb48.8 Mb49 Mb49.2 Mb49.4 MbSULT2B1: 48,552,140–48,599,425, forward strandSACK1E: 48,599,961–48,615,093, reverse strandSPACA4: 48,606,742–48,607,962, forward strandRPL18: 48,615,284–48,619,213, reverse strandRPL18SPHK2: 48,619,291–48,630,717, forward strandSPHK2DBP: 48,630,030–48,637,695, reverse strandDBPCA11: 48,637,946–48,646,386, reverse strandCA11NTN5: 48,661,407–48,673,081, reverse strandNTN5FUT2: 48,695,953–48,705,951, forward strandFUT2MAMSTR: 48,711,737–48,719,966, reverse strandRASIP1: 48,720,571–48,740,616, reverse strandRASIP1IZUMO1: 48,740,852–48,746,909, reverse strandIZUMO1FUT1: 48,748,011–48,755,390, reverse strandFUT1FGF21: 48,755,524–48,758,333, forward strandFGF21BCAT2: 48,795,061–48,811,066, reverse strandBCAT2HSD17B14: 48,813,014–48,837,064, reverse strandHSD17B14PLEKHA4: 48,837,091–48,868,855, reverse strandPLEKHA4PPP1R15A: 48,872,212–48,879,061, forward strandPPP1R15ATULP2: 48,880,965–48,898,744, reverse strandTULP2NUCB1: 48,900,050–48,923,958, forward strandNUCB1DHDH: 48,933,517–48,944,969, forward strandDHDHBAX: 48,954,815–48,961,806, forward strandBAXFTL: 48,965,275–48,967,896, forward strandFTLGYS1: 48,968,125–48,993,349, reverse strandRUVBL2: 48,993,476–49,017,868, forward strandRUVBL2LHB: 49,015,980–49,017,091, reverse strandLHBSAXO3: 49,017,968–49,020,549, reverse strandSAXO3CGB3: 49,022,869–49,024,360, reverse strandCGB3: 49,022,953–49,036,895, reverse strandCGB2: 49,031,890–49,033,238, forward strandCGB1: 49,035,569–49,036,895, reverse strandCGB5: 49,043,595–49,045,312, forward strandCGB8: 49,047,638–49,049,125, reverse strandCGB7: 49,054,274–49,058,860, reverse strand: 49,055,793–49,065,076, reverse strandNTF4: 49,061,066–49,065,076, reverse strandKCNA7: 49,067,397–49,072,702, reverse strandKCNA7SNRNP70: 49,085,164–49,108,618, forward strandSNRNP70LIN7B: 49,114,324–49,118,463, forward strandLIN7BC19orf73: 49,118,402–49,119,143, reverse strandC19orf73PPFIA3: 49,119,401–49,151,027, forward strandPPFIA3HRC: 49,151,014–49,155,441, reverse strandHRCTRPM4: 49,157,737–49,211,841, forward strandTRPM4SLC6A16: 49,289,638–49,325,215, reverse strandSLC6A16CD37: 49,335,171–49,343,335, forward strandCD37TEAD2: 49,340,389–49,362,729, reverse strandTEAD2DKKL1: 49,361,783–49,375,120, forward strandDKKL1KASH5: 49,388,219–49,417,990, forward strandKASH5PTH2: 49,422,419–49,423,660, reverse strandPTH2GFY: 49,423,749–49,428,987, forward strandGFYSLC17A7: 49,429,399–49,443,197, reverse strandSLC17A7PIH1D1: 49,446,291–49,453,537, reverse strandALDH16A1: 49,453,146–49,471,052, forward strand: 49,462,752–49,486,231, forward strandFLT3LG: 49,474,150–49,486,233, forward strandRPL13A: 49,487,510–49,493,057, forward strandRPS11: 49,496,233–49,499,903, forward strandRPS11FCGRT: 49,506,806–49,526,917, forward strandFCGRTDiagram of LHB: 3 exons on the reverse strand of chromosome 19Exon 3: 49,015,980–49,016,310, 331 basesExon 2: 49,016,547–49,016,714, 168 basesExon 1: 49,017,067–49,017,091, 25 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.5 kb of the gene's 1.1 kb; 426 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LHB gene: luteinizing hormone subunit beta. Retrieved 17 October 2026, from https://dantelabs.com/genes/lhb

Vancouver

Dante Labs. LHB gene: luteinizing hormone subunit beta [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lhb

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