Trait
Obstructive azoospermia
Absence of any measurable level of sperm in his semen, resulting from post-testicular obstruction or retrograde ejaculation. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy.
Summary
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
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Get my Genome Test39 genes linked to Obstructive azoospermia
Changes in these genes cause rare conditions in which Obstructive azoospermia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CLDN2claudin 2 | Always | In 1 condition |
| ADGRG2adhesion G protein-coupled receptor G2 | Very often (80–99%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Very often (80–99%) | In 2 conditions |
| CATIPciliogenesis associated TTC17 interacting protein | Often (30–79%) | In 1 condition |
| CCDC34coiled-coil domain containing 34 | Often (30–79%) | In 1 condition |
| CT55cancer/testis antigen 55 | Often (30–79%) | In 1 condition |
| DNAH10dynein axonemal heavy chain 10 | Often (30–79%) | In 1 condition |
| DNHD1dynein heavy chain domain 1 | Often (30–79%) | In 1 condition |
| FANCMFA complementation group M | Often (30–79%) | In 1 condition |
| FBXO43F-box protein 43 | Often (30–79%) | In 1 condition |
| GCNAgerm cell nuclear acidic peptidase | Often (30–79%) | In 1 condition |
| KLHL10kelch like family member 10 | Often (30–79%) | In 1 condition |
| MEIOBmeiosis specific with OB-fold | Often (30–79%) | In 1 condition |
| MOV10L1Mov10 like RNA helicase 1 | Often (30–79%) | In 1 condition |
| MSH5mutS homolog 5 | Often (30–79%) | In 1 condition |
| NANOS1nanos C2HC-type zinc finger 1 | Often (30–79%) | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Often (30–79%) | In 1 condition |
| PDHA2pyruvate dehydrogenase E1 subunit alpha 2 | Often (30–79%) | In 1 condition |
| PNLDC1PARN like ribonuclease domain containing exonuclease 1 | Often (30–79%) | In 1 condition |
| RBBP7RB binding protein 7, chromatin remodeling factor | Often (30–79%) | In 1 condition |
| RNF212ring finger protein 212 | Often (30–79%) | In 1 condition |
| RPL10Lribosomal protein L10 like | Often (30–79%) | In 1 condition |
| SHOC1shortage in chiasmata 1 | Often (30–79%) | In 1 condition |
| SOHLH1spermatogenesis and oogenesis specific basic helix-loop-helix 1 | Often (30–79%) | In 1 condition |
| SPAG17sperm associated antigen 17 | Often (30–79%) | In 1 condition |
| SPINK2serine peptidase inhibitor Kazal type 2 | Often (30–79%) | In 1 condition |
| STAG3STAG3 cohesin complex component | Often (30–79%) | In 1 condition |
| SYCE1synaptonemal complex central element protein 1 | Often (30–79%) | In 1 condition |
| SYCP3synaptonemal complex protein 3 | Often (30–79%) | In 1 condition |
| TAF4BTATA-box binding protein associated factor 4b | Often (30–79%) | In 1 condition |
| TDRD9tudor domain containing 9 | Often (30–79%) | In 1 condition |
| TERB1telomere repeat binding bouquet formation protein 1 | Often (30–79%) | In 1 condition |
| TERB2telomere repeat binding bouquet formation protein 2 | Often (30–79%) | In 1 condition |
| TEX11testis expressed 11 | Often (30–79%) | In 1 condition |
| TEX14testis expressed 14, intercellular bridge forming factor | Often (30–79%) | In 1 condition |
| TEX15testis expressed 15, meiosis and synapsis associated | Often (30–79%) | In 1 condition |
| XRCC2X-ray repair cross complementing 2 | Often (30–79%) | In 1 condition |
| ZMYND15zinc finger MYND-type containing 15 | Often (30–79%) | In 1 condition |
| ZSWIM7zinc finger SWIM-type containing 7 | Often (30–79%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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