Trait
Non-obstructive azoospermia
Absence of any measurable level of sperm in his semen, resulting from a defect in the production of spermatozoa in the testes. This can be differentiated from obstructive azoospermia on the basis of testicular biopsy.
Summary
- Also called
- Testicular azoospermia
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test69 genes linked to Non-obstructive azoospermia
Changes in these genes cause rare conditions in which Non-obstructive azoospermia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATG4Dautophagy related 4D cysteine peptidase | Always | In 1 condition |
| FANCMFA complementation group M | Always | In 2 conditions |
| KASH5KASH domain containing 5 | Always | In 1 condition |
| MOV10L1Mov10 like RNA helicase 1 | Always | In 2 conditions |
| MSH4mutS homolog 4 | Always | In 1 condition |
| MSH5mutS homolog 5 | Always | In 2 conditions |
| PNLDC1PARN like ribonuclease domain containing exonuclease 1 | Always | In 2 conditions |
| RBBP7RB binding protein 7, chromatin remodeling factor | Always | In 2 conditions |
| RNF212ring finger protein 212 | Always | In 2 conditions |
| SHOC1shortage in chiasmata 1 | Always | In 2 conditions |
| SOHLH1spermatogenesis and oogenesis specific basic helix-loop-helix 1 | Always | In 2 conditions |
| SOX9SRY-box transcription factor 9 | Always | In 1 condition |
| SPATA22spermatogenesis associated 22 | Always | In 1 condition |
| SPINK2serine peptidase inhibitor Kazal type 2 | Always | In 2 conditions |
| STAG3STAG3 cohesin complex component | Always | In 2 conditions |
| SYCE1synaptonemal complex central element protein 1 | Always | In 2 conditions |
| TERB1telomere repeat binding bouquet formation protein 1 | Always | In 2 conditions |
| TERB2telomere repeat binding bouquet formation protein 2 | Always | In 2 conditions |
| ZSWIM7zinc finger SWIM-type containing 7 | Always | In 2 conditions |
| CATIPciliogenesis associated TTC17 interacting protein | Very often (80–99%) | In 1 condition |
| CCDC34coiled-coil domain containing 34 | Very often (80–99%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Very often (80–99%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Very often (80–99%) | In 1 condition |
| CT55cancer/testis antigen 55 | Very often (80–99%) | In 1 condition |
| DAZ1deleted in azoospermia 1 | Very often (80–99%) | In 1 condition |
| DAZ2deleted in azoospermia 2 | Very often (80–99%) | In 1 condition |
| DAZ3deleted in azoospermia 3 | Very often (80–99%) | In 1 condition |
| DAZ4deleted in azoospermia 4 | Very often (80–99%) | In 1 condition |
| DDX3YDEAD-box helicase 3 Y-linked | Very often (80–99%) | In 1 condition |
| DNAH10dynein axonemal heavy chain 10 | Very often (80–99%) | In 1 condition |
| DNHD1dynein heavy chain domain 1 | Very often (80–99%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Very often (80–99%) | In 1 condition |
| EMX2empty spiracles homeobox 2 | Very often (80–99%) | In 1 condition |
| FBXO43F-box protein 43 | Very often (80–99%) | In 1 condition |
| FGF17fibroblast growth factor 17 | Very often (80–99%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Very often (80–99%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Very often (80–99%) | In 1 condition |
| GCNAgerm cell nuclear acidic peptidase | Very often (80–99%) | In 1 condition |
| GNRH1gonadotropin releasing hormone 1 | Very often (80–99%) | In 1 condition |
| GNRHRgonadotropin releasing hormone receptor | Very often (80–99%) | In 1 condition |
Show 29 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Very often (80–99%) | In 1 condition |
| KISS1KiSS-1 metastasis suppressor | Very often (80–99%) | In 1 condition |
| KISS1RKISS1 receptor | Very often (80–99%) | In 1 condition |
| KLHL10kelch like family member 10 | Very often (80–99%) | In 1 condition |
| MEIOBmeiosis specific with OB-fold | Very often (80–99%) | In 2 conditions |
| NANOS1nanos C2HC-type zinc finger 1 | Very often (80–99%) | In 1 condition |
| NHLH2nescient helix-loop-helix 2 | Very often (80–99%) | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Very often (80–99%) | In 1 condition |
| NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor | Very often (80–99%) | In 1 condition |
| PDHA2pyruvate dehydrogenase E1 subunit alpha 2 | Very often (80–99%) | In 1 condition |
| PROK2prokineticin 2 | Very often (80–99%) | In 1 condition |
| PROKR2prokineticin receptor 2 | Very often (80–99%) | In 1 condition |
| RBMY1A1RNA binding motif protein Y-linked family 1 member A1 | Very often (80–99%) | In 1 condition |
| RPL10Lribosomal protein L10 like | Very often (80–99%) | In 1 condition |
| SPAG17sperm associated antigen 17 | Very often (80–99%) | In 1 condition |
| SPRY4sprouty RTK signaling antagonist 4 | Very often (80–99%) | In 1 condition |
| SYCP3synaptonemal complex protein 3 | Very often (80–99%) | In 1 condition |
| TAC3tachykinin precursor 3 | Very often (80–99%) | In 1 condition |
| TACR3tachykinin receptor 3 | Very often (80–99%) | In 1 condition |
| TAF4BTATA-box binding protein associated factor 4b | Very often (80–99%) | In 1 condition |
| TDRD9tudor domain containing 9 | Very often (80–99%) | In 1 condition |
| TEX11testis expressed 11 | Very often (80–99%) | In 1 condition |
| TEX14testis expressed 14, intercellular bridge forming factor | Very often (80–99%) | In 1 condition |
| TEX15testis expressed 15, meiosis and synapsis associated | Very often (80–99%) | In 2 conditions |
| TSPY1testis specific protein Y-linked 1 | Very often (80–99%) | In 1 condition |
| USP9Yubiquitin specific peptidase 9 Y-linked | Very often (80–99%) | In 1 condition |
| WDR11WD repeat domain 11 | Very often (80–99%) | In 1 condition |
| XRCC2X-ray repair cross complementing 2 | Very often (80–99%) | In 1 condition |
| ZMYND15zinc finger MYND-type containing 15 | Very often (80–99%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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