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Gene

ADGRV1

adhesion G protein-coupled receptor V1

Summary

Cytogenetic location
5q14.3
Coordinates
Chromosome 5: 90,558,797–91,164,437 (GRCh38)
Exons
90 exons across 605.6 kb
Protein
6,306 amino acids
Inheritance
Autosomal recessive
Also known as
DKFZp761P0710, KIAA0686, FEB4, VLGR1
Previous symbols
USH2C, MASS1, GPR98
MANE Select transcript
ENST00000405460.9NM_032119.4
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Usher Syndrome

    • Autosomal recessive

      A group of recessive conditions (types 1 to 4) causing sensorineural hearing loss, progressive retinitis pigmentosa and, in some types, balance problems, linked to genes such as USH2A, MYO7A, CDH23, PCDH15, USH1C, USH1G, ADGRV1, WHRN, CLRN1 and ARSG.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      An early diagnosis helps with decisions about the timing of cochlear implants, eye monitoring and eligibility for retinal therapy trials, and is relevant to carrier screening.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ADGRV1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where ADGRV1 sits. ADGRV1 and 5 genes near it on chromosome 5, from 89,953,156 to 91,770,078.Chromosome 55q14.3p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.390 Mb90.5 Mb91 Mb91.5 MbCETN3: 90,389,658–90,409,793, reverse strandCETN3MBLAC2: 90,457,960–90,474,786, reverse strandMBLAC2POLR3G: 90,471,748–90,514,559, forward strandPOLR3GLYSMD3: 90,512,565–90,529,745, reverse strandLYSMD3ADGRV1: 90,558,797–91,164,437, forward strandADGRV1ARRDC3: 91,368,631–91,383,348, reverse strandARRDC3Diagram of ADGRV1: 90 exons on the forward strand of chromosome 5Exon 1: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 7: 3 known disease-causing sitesExon 8: 1 known disease-causing siteExon 9: 3 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 15: 5 known disease-causing sitesExon 17: 3 known disease-causing sitesExon 18: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 20: 6 known disease-causing sitesExon 21: 1 known disease-causing siteExon 22: 2 known disease-causing sitesExon 23: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 28: 6 known disease-causing sitesExon 30: 2 known disease-causing sitesExon 31: 2 known disease-causing sitesExon 32: 5 known disease-causing sitesExon 33: 1 known disease-causing siteExon 36: 1 known disease-causing siteExon 37: 1 known disease-causing siteExon 38: 1 known disease-causing siteExon 39: 3 known disease-causing sitesExon 40: 2 known disease-causing sitesExon 41: 1 known disease-causing siteExon 43: 2 known disease-causing sitesExon 44: 1 known disease-causing siteExon 45: 1 known disease-causing siteExon 46: 2 known disease-causing sitesExon 48: 2 known disease-causing sitesExon 49: 3 known disease-causing sitesExon 50: 2 known disease-causing sitesExon 51: 1 known disease-causing siteExon 53: 2 known disease-causing sitesExon 54: 1 known disease-causing siteExon 55: 3 known disease-causing sitesExon 57: 1 known disease-causing siteExon 59: 1 known disease-causing siteExon 60: 2 known disease-causing sitesExon 61: 2 known disease-causing sitesExon 62: 2 known disease-causing sitesExon 63: 4 known disease-causing sitesExon 65: 1 known disease-causing siteExon 66: 1 known disease-causing siteExon 67: 1 known disease-causing siteExon 68: 3 known disease-causing sitesExon 70: 5 known disease-causing sitesExon 72: 1 known disease-causing siteExon 73: 2 known disease-causing sitesExon 74: 1 known disease-causing siteExon 76: 3 known disease-causing sitesExon 77: 1 known disease-causing siteExon 79: 3 known disease-causing sitesExon 80: 2 known disease-causing sitesExon 81: 2 known disease-causing sitesExon 82: 2 known disease-causing sitesExon 84: 2 known disease-causing sitesExon 89: 2 known disease-causing sitesExon 1: 90,558,797–90,558,917, 121 basesExon 2: 90,614,835–90,615,019, 185 basesExon 3: 90,617,804–90,617,953, 150 basesExon 4: 90,619,086–90,619,181, 96 basesExon 5: 90,622,597–90,622,701, 105 basesExon 6: 90,625,130–90,625,243, 114 basesExon 7: 90,627,211–90,627,776, 566 basesExon 8: 90,628,562–90,628,832, 271 basesExon 9: 90,629,210–90,629,539, 330 basesExon 10: 90,635,114–90,635,290, 177 basesExon 11: 90,637,725–90,637,948, 224 basesExon 12: 90,642,636–90,642,762, 127 basesExon 13: 90,642,856–90,643,041, 186 basesExon 14: 90,643,803–90,643,983, 181 basesExon 15: 90,644,706–90,644,869, 164 basesExon 16: 90,645,968–90,646,091, 124 basesExon 17: 90,647,498–90,647,764, 267 basesExon 18: 90,651,604–90,651,730, 127 basesExon 19: 90,652,346–90,652,563, 218 basesExon 20: 90,653,209–90,653,952, 744 basesExon 21: 90,657,905–90,658,278, 374 basesExon 22: 90,672,546–90,672,722, 177 basesExon 23: 90,674,054–90,674,234, 181 basesExon 24: 90,675,243–90,675,445, 203 basesExon 25: 90,676,080–90,676,209, 130 basesExon 26: 90,679,549–90,679,629, 81 basesExon 27: 90,681,315–90,681,454, 140 basesExon 28: 90,683,586–90,684,195, 610 basesExon 29: 90,685,780–90,685,995, 216 basesExon 30: 90,689,861–90,690,076, 216 basesExon 31: 90,690,797–90,691,041, 245 basesExon 32: 90,692,605–90,692,786, 182 basesExon 33: 90,693,890–90,694,701, 812 basesExon 34: 90,696,937–90,697,146, 210 basesExon 35: 90,703,665–90,703,795, 131 basesExon 36: 90,704,389–90,704,488, 100 basesExon 37: 90,705,400–90,705,579, 180 basesExon 38: 90,706,231–90,706,394, 164 basesExon 39: 90,708,816–90,708,909, 94 basesExon 40: 90,710,981–90,711,059, 79 basesExon 41: 90,711,184–90,711,322, 139 basesExon 42: 90,712,287–90,712,428, 142 basesExon 43: 90,716,467–90,716,729, 263 basesExon 44: 90,720,048–90,720,223, 176 basesExon 45: 90,720,935–90,721,059, 125 basesExon 46: 90,724,832–90,724,989, 158 basesExon 47: 90,725,086–90,725,232, 147 basesExon 48: 90,725,549–90,725,656, 108 basesExon 49: 90,728,669–90,728,933, 265 basesExon 50: 90,729,642–90,729,764, 123 basesExon 51: 90,745,046–90,745,265, 220 basesExon 52: 90,745,591–90,745,795, 205 basesExon 53: 90,750,551–90,750,697, 147 basesExon 54: 90,753,574–90,753,829, 256 basesExon 55: 90,754,983–90,755,185, 203 basesExon 56: 90,756,454–90,756,630, 177 basesExon 57: 90,756,979–90,757,161, 183 basesExon 58: 90,759,409–90,759,588, 180 basesExon 59: 90,763,305–90,763,469, 165 basesExon 60: 90,774,186–90,774,303, 118 basesExon 61: 90,776,453–90,776,576, 124 basesExon 62: 90,777,905–90,778,043, 139 basesExon 63: 90,778,427–90,778,609, 183 basesExon 64: 90,778,865–90,779,097, 233 basesExon 65: 90,781,430–90,781,578, 149 basesExon 66: 90,783,124–90,783,325, 202 basesExon 67: 90,783,838–90,784,057, 220 basesExon 68: 90,788,071–90,788,310, 240 basesExon 69: 90,789,702–90,789,851, 150 basesExon 70: 90,790,873–90,791,346, 474 basesExon 71: 90,802,739–90,802,882, 144 basesExon 72: 90,805,284–90,805,458, 175 basesExon 73: 90,807,602–90,807,737, 136 basesExon 74: 90,810,233–90,811,338, 1,106 basesExon 75: 90,815,619–90,815,736, 118 basesExon 76: 90,823,425–90,823,596, 172 basesExon 77: 90,828,944–90,829,186, 243 basesExon 78: 90,840,578–90,840,985, 408 basesExon 79: 90,848,637–90,848,821, 185 basesExon 80: 90,853,284–90,853,533, 250 basesExon 81: 90,854,062–90,854,201, 140 basesExon 82: 90,855,741–90,855,901, 161 basesExon 83: 90,863,757–90,863,857, 101 basesExon 84: 90,965,415–90,965,531, 117 basesExon 85: 90,985,344–90,985,522, 179 basesExon 86: 91,072,447–91,072,604, 158 basesExon 87: 91,102,219–91,102,340, 122 basesExon 88: 91,150,030–91,150,221, 192 basesExon 89: 91,153,221–91,153,398, 178 basesExon 90: 91,163,782–91,164,437, 656 bases11020304050607080905′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 19.6 kb of the gene's 605.6 kb; 18,921 of those bases code for the protein.

How a genome test reads ADGRV1

160

positions in ADGRV1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 605.6 kb of ADGRV1, introns included, not only the 19.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ADGRV1 gene: adhesion G protein-coupled receptor V1. Retrieved 17 October 2026, from https://dantelabs.com/genes/adgrv1

Vancouver

Dante Labs. ADGRV1 gene: adhesion G protein-coupled receptor V1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/adgrv1

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