Skip to content
Use your HSA or FSA funds

Gene

ARSG

arylsulfatase G

Summary

Cytogenetic location
17q24.2
Coordinates
Chromosome 17: 68,291,495–68,420,814 (GRCh38)
Exons
12 exons across 129.3 kb
Protein
525 amino acids
Inheritance
Autosomal recessive
Also known as
KIAA1001
MANE Select transcript
ENST00000621439.5NM_001267727.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Usher Syndrome

    • Autosomal recessive

      A group of recessive conditions (types 1 to 4) causing sensorineural hearing loss, progressive retinitis pigmentosa and, in some types, balance problems, linked to genes such as USH2A, MYO7A, CDH23, PCDH15, USH1C, USH1G, ADGRV1, WHRN, CLRN1 and ARSG.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      An early diagnosis helps with decisions about the timing of cochlear implants, eye monitoring and eligibility for retinal therapy trials, and is relevant to carrier screening.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ARSG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where ARSG sits. ARSG and 8 genes near it on chromosome 17, from 67,856,155 to 68,856,154.Chromosome 1717q24.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.368 Mb68.2 Mb68.4 Mb68.6 Mb68.8 MbBPTF: 67,825,488–67,984,378, forward strandBPTFC17orf58: 67,991,099–67,996,473, reverse strandC17orf58KPNA2: 68,035,517–68,047,364, forward strandKPNA2AMZ2: 68,205,431–68,258,828, forward strandAMZ2SLC16A6: 68,267,026–68,291,267, reverse strandSLC16A6ARSG: 68,291,495–68,420,814, forward strandARSGWIPI1: 68,420,948–68,457,563, reverse strandWIPI1PRKAR1A: 68,511,740–68,551,319, forward strandPRKAR1AFAM20A: 68,535,113–68,601,407, reverse strandFAM20ADiagram of ARSG: 12 exons on the forward strand of chromosome 17Exon 7: 1 known disease-causing siteExon 1: 68,291,495–68,291,568, 74 basesExon 2: 68,306,943–68,307,711, 769 basesExon 3: 68,343,604–68,343,791, 188 basesExon 4: 68,347,125–68,347,172, 48 basesExon 5: 68,351,575–68,351,686, 112 basesExon 6: 68,356,667–68,356,804, 138 basesExon 7: 68,368,548–68,368,744, 197 basesExon 8: 68,370,444–68,370,524, 81 basesExon 9: 68,385,064–68,385,172, 109 basesExon 10: 68,395,073–68,395,193, 121 basesExon 11: 68,401,360–68,401,450, 91 basesExon 12: 68,420,189–68,420,814, 626 bases1246810125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 129.3 kb; 1,578 of those bases code for the protein.

How a genome test reads ARSG

5

positions in ARSG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 129.3 kb of ARSG, introns included, not only the 2.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ARSG gene: arylsulfatase G. Retrieved 16 October 2026, from https://dantelabs.com/genes/arsg

Vancouver

Dante Labs. ARSG gene: arylsulfatase G [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/arsg

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test