Trait
Knee joint over-flexibility
Clinical name: Knee joint hypermobility
The ability of the knee to move past its normal range of motion, (knee hyperextension is greater than 10 degrees).
Summary
Reference genomeGRCh38hg38
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Get my Genome Test5 genes linked to Knee joint over-flexibility
Changes in these genes cause rare conditions in which Knee joint over-flexibility is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| COMPcartilage oligomeric matrix protein | Often (30–79%) | In 2 conditions |
| FGFR3fibroblast growth factor receptor 3 | Often (30–79%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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