Trait
Knee pain
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the knee.
Summary
- Also called
- Pain under knee cap
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test20 genes linked to Knee pain
Changes in these genes cause rare conditions in which Knee pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| COL11A1collagen type XI alpha 1 chain | Always | In 1 condition |
| COL9A1collagen type IX alpha 1 chain | Always | In 2 conditions |
| HYAL1hyaluronidase 1 | Always | In 1 condition |
| LRP6LDL receptor related protein 6 | Always | In 1 condition |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Always | In 2 conditions |
| TBXAS1thromboxane A synthase 1 | Always | In 1 condition |
| COL9A2collagen type IX alpha 2 chain | Often (30–79%) | In 2 conditions |
| COL9A3collagen type IX alpha 3 chain | Often (30–79%) | In 2 conditions |
| COMPcartilage oligomeric matrix protein | Often (30–79%) | In 1 condition |
| MATN3matrilin 3 | Often (30–79%) | In 1 condition |
| MMP13matrix metallopeptidase 13 | Often (30–79%) | In 1 condition |
| TRAPPC2trafficking protein particle complex subunit 2 | Often (30–79%) | In 1 condition |
| B2Mbeta-2-microglobulin | Sometimes (5–29%) | In 1 condition |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Sometimes (5–29%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Sometimes (5–29%) | In 1 condition |
| GJB2gap junction protein beta 2 | Rarely (1–4%) | In 1 condition |
| GJB6gap junction protein beta 6 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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