Trait
Difficulties with night vision
Clinical name: Nyctalopia
Inability to see well at night or in poor light.
Summary
- Also called
- Night blindness, Night-blindness, Poor night vision
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
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Read the genes linked to Difficulties with night vision, and the rest of your genome, with one test.
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Get my Genome Test232 genes linked to Difficulties with night vision
Changes in these genes cause rare conditions in which Difficulties with night vision is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARHGEF18Rho/Rac guanine nucleotide exchange factor 18 | Always | In 2 conditions |
| ARL3ARF like GTPase 3 | Always | In 3 conditions |
| ARL6ARF like GTPase 6 | Always | In 5 conditions |
| ARSGarylsulfatase G | Always | In 2 conditions |
| BBS1Bardet-Biedl syndrome 1 | Always | In 3 conditions |
| BBS2Bardet-Biedl syndrome 2 | Always | In 3 conditions |
| BBS4Bardet-Biedl syndrome 4 | Always | In 2 conditions |
| BBS5Bardet-Biedl syndrome 5 | Always | In 2 conditions |
| CCDC28Bcoiled-coil domain containing 28B | Always | In 1 condition |
| CFAP20cilia and flagella associated protein 20 | Always | In 2 conditions |
| CFAP410cilia and flagella associated protein 410 | Always | In 2 conditions |
| CHMCHM Rab escort protein | Always | In 2 conditions |
| CLEC3BC-type lectin domain family 3 member B | Always | In 1 condition |
| CLN3CLN3 lysosomal/endosomal transmembrane protein, battenin | Always | In 1 condition |
| CNGA1cyclic nucleotide gated channel subunit alpha 1 | Always | In 3 conditions |
| CNGB1cyclic nucleotide gated channel subunit beta 1 | Always | In 2 conditions |
| CWC27CWC27 spliceosome associated cyclophilin | Always | In 2 conditions |
| DHDDSdehydrodolichyl diphosphate synthase subunit | Always | In 2 conditions |
| DHX38DEAH-box helicase 38 | Always | In 2 conditions |
| ESPNespin | Always | In 2 conditions |
| FSD1Lfibronectin type III and SPRY domain containing 1 like | Always | In 3 conditions |
| GGCXgamma-glutamyl carboxylase | Always | In 1 condition |
| GRM6glutamate metabotropic receptor 6 | Always | In 1 condition |
| GUCY2Dguanylate cyclase 2D, retinal | Always | In 5 conditions |
| HKDC1hexokinase domain containing 1 | Always | In 2 conditions |
| IDH3Aisocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha | Always | In 2 conditions |
| IDH3Gisocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma | Always | In 1 condition |
| IFT140intraflagellar transport 140 | Always | In 2 conditions |
| IFT172intraflagellar transport 172 | Always | In 5 conditions |
| IFT43intraflagellar transport 43 | Always | In 2 conditions |
| IMPDH1inosine monophosphate dehydrogenase 1 | Always | In 2 conditions |
| KIAA1549KIAA1549 | Always | In 2 conditions |
| KIZkizuna centrosomal protein | Always | In 2 conditions |
| LRIT3leucine rich repeat, Ig-like and transmembrane domains 3 | Always | In 1 condition |
| MERTKMER proto-oncogene, tyrosine kinase | Always | In 2 conditions |
| MFRPmembrane frizzled-related protein | Always | In 1 condition |
| NR2E3nuclear receptor subfamily 2 group E member 3 | Always | In 3 conditions |
| NRLneural retina leucine zipper | Always | In 3 conditions |
| OATornithine aminotransferase | Always | In 1 condition |
| PDE6Aphosphodiesterase 6A | Always | In 2 conditions |
Show 192 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PDE6Bphosphodiesterase 6B | Always | In 2 conditions |
| PEX7peroxisomal biogenesis factor 7 | Always | In 3 conditions |
| POMGNT1protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | Always | In 2 conditions |
| PRPF6pre-mRNA processing factor 6 | Always | In 2 conditions |
| RBP4retinol binding protein 4 | Always | In 1 condition |
| RDH11retinol dehydrogenase 11 | Always | In 1 condition |
| REEP6receptor accessory protein 6 | Always | In 2 conditions |
| RHOrhodopsin | Always | In 4 conditions |
| RLBP1retinaldehyde binding protein 1 | Always | In 6 conditions |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| RP1L1RP1 like 1 | Always | In 2 conditions |
| RPE65retinoid isomerohydrolase RPE65 | Always | In 4 conditions |
| RPGRretinitis pigmentosa GTPase regulator | Always | In 4 conditions |
| SCAPERS-phase cyclin A associated protein in the ER | Always | In 3 conditions |
| SLC7A14solute carrier family 7 member 14 | Always | In 2 conditions |
| TBC1D32TBC1 domain family member 32 | Always | In 1 condition |
| TMEM216transmembrane protein 216 | Always | In 2 conditions |
| TRNT1tRNA nucleotidyl transferase 1 | Always | In 1 condition |
| TULP1TUB like protein 1 | Always | In 3 conditions |
| UBAP1Lubiquitin associated protein 1 like | Always | In 2 conditions |
| VWA8von Willebrand factor A domain containing 8 | Always | In 1 condition |
| WHRNwhirlin | Always | In 2 conditions |
| YARS1tyrosyl-tRNA synthetase 1 | Always | In 1 condition |
| ZNF408zinc finger protein 408 | Always | In 2 conditions |
| ZNF513zinc finger protein 513 | Always | In 2 conditions |
| ABCA4ATP binding cassette subfamily A member 4 | Very often (80–99%) | In 4 conditions |
| ADAM9ADAM metallopeptidase domain 9 | Very often (80–99%) | In 1 condition |
| AIPL1AIP like 1 HSP90 co-chaperone | Very often (80–99%) | In 3 conditions |
| ATF6activating transcription factor 6 | Very often (80–99%) | In 1 condition |
| CACNA1Fcalcium voltage-gated channel subunit alpha1 F | Very often (80–99%) | In 1 condition |
| CACNA2D4calcium voltage-gated channel auxiliary subunit alpha2delta 4 | Very often (80–99%) | In 1 condition |
| CDH23cadherin related 23 | Very often (80–99%) | In 1 condition |
| CDHR1cadherin related family member 1 | Very often (80–99%) | In 3 conditions |
| CEP78centrosomal protein 78 | Very often (80–99%) | In 1 condition |
| CFAP418cilia and flagella associated protein 418 | Very often (80–99%) | In 5 conditions |
| CLRN1clarin 1 | Very often (80–99%) | In 5 conditions |
| CNGA3cyclic nucleotide gated channel subunit alpha 3 | Very often (80–99%) | In 1 condition |
| CNGB3cyclic nucleotide gated channel subunit beta 3 | Very often (80–99%) | In 1 condition |
| CRXcone-rod homeobox | Very often (80–99%) | In 4 conditions |
| DRAM2DNA damage regulated autophagy modulator 2 | Very often (80–99%) | In 2 conditions |
| ELOVL4ELOVL fatty acid elongase 4 | Very often (80–99%) | In 1 condition |
| GUCA1Aguanylate cyclase activator 1A | Very often (80–99%) | In 2 conditions |
| HARS1histidyl-tRNA synthetase 1 | Very often (80–99%) | In 1 condition |
| HGSNATheparan-alpha-glucosaminide N-acetyltransferase | Very often (80–99%) | In 2 conditions |
| MAKmale germ cell associated kinase | Very often (80–99%) | In 2 conditions |
| MFSD8major facilitator superfamily domain containing 8 | Very often (80–99%) | In 1 condition |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Very often (80–99%) | In 1 condition |
| MYO7Amyosin VIIA | Very often (80–99%) | In 2 conditions |
| NMNAT1nicotinamide nucleotide adenylyltransferase 1 | Very often (80–99%) | In 2 conditions |
| OPN1LWopsin 1, long wave sensitive | Very often (80–99%) | In 1 condition |
| OPN1MWopsin 1, medium wave sensitive | Very often (80–99%) | In 1 condition |
| PCDH15protocadherin related 15 | Very often (80–99%) | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Very often (80–99%) | In 1 condition |
| PEX10peroxisomal biogenesis factor 10 | Very often (80–99%) | In 1 condition |
| PEX11Bperoxisomal biogenesis factor 11 beta | Very often (80–99%) | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Very often (80–99%) | In 1 condition |
| PEX13peroxisomal biogenesis factor 13 | Very often (80–99%) | In 1 condition |
| PEX14peroxisomal biogenesis factor 14 | Very often (80–99%) | In 1 condition |
| PEX16peroxisomal biogenesis factor 16 | Very often (80–99%) | In 1 condition |
| PEX19peroxisomal biogenesis factor 19 | Very often (80–99%) | In 1 condition |
| PEX2peroxisomal biogenesis factor 2 | Very often (80–99%) | In 1 condition |
| PEX26peroxisomal biogenesis factor 26 | Very often (80–99%) | In 1 condition |
| PEX3peroxisomal biogenesis factor 3 | Very often (80–99%) | In 1 condition |
| PEX5peroxisomal biogenesis factor 5 | Very often (80–99%) | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Very often (80–99%) | In 1 condition |
| PITPNM3PITPNM family member 3 | Very often (80–99%) | In 1 condition |
| POC1BPOC1 centriolar protein B | Very often (80–99%) | In 1 condition |
| PROM1prominin 1 | Very often (80–99%) | In 5 conditions |
| PRPF31pre-mRNA processing factor 31 | Very often (80–99%) | In 2 conditions |
| PRPF4pre-mRNA splicing tri-snRNP complex factor PRPF4 | Very often (80–99%) | In 2 conditions |
| PRPF8pre-mRNA processing factor 8 | Very often (80–99%) | In 2 conditions |
| PRPH2peripherin 2 | Very often (80–99%) | In 9 conditions |
| RAB28RAB28, member RAS oncogene family | Very often (80–99%) | In 1 condition |
| RAX2retina and anterior neural fold homeobox 2 | Very often (80–99%) | In 1 condition |
| RDH5retinol dehydrogenase 5 | Very often (80–99%) | In 2 conditions |
| RIMS1regulating synaptic membrane exocytosis 1 | Very often (80–99%) | In 1 condition |
| RP1RP1 axonemal microtubule associated | Very often (80–99%) | In 2 conditions |
| RPGRIP1RPGR interacting protein 1 | Very often (80–99%) | In 3 conditions |
| SEMA4Asemaphorin 4A | Very often (80–99%) | In 4 conditions |
| TLCD3BTLC domain containing 3B | Very often (80–99%) | In 1 condition |
| TTLL5tubulin tyrosine ligase like 5 | Very often (80–99%) | In 1 condition |
| UNC119unc-119 lipid binding chaperone | Very often (80–99%) | In 2 conditions |
| USH1CUSH1 protein network component harmonin | Very often (80–99%) | In 1 condition |
| USH1GUSH1 protein network component sans | Very often (80–99%) | In 1 condition |
| VPS13Bvacuolar protein sorting 13 homolog B | Very often (80–99%) | In 1 condition |
| ADGRV1adhesion G protein-coupled receptor V1 | Often (30–79%) | In 1 condition |
| AGBL1AGBL carboxypeptidase 1 | Often (30–79%) | In 1 condition |
| AGBL5AGBL carboxypeptidase 5 | Often (30–79%) | In 2 conditions |
| AHI1Abelson helper integration site 1 | Often (30–79%) | In 1 condition |
| AHRaryl hydrocarbon receptor | Often (30–79%) | In 1 condition |
| ALMS1ALMS1 centrosome and basal body associated protein | Often (30–79%) | In 1 condition |
| ARL2BPARF like GTPase 2 binding protein | Often (30–79%) | In 1 condition |
| BBIP1BBSome interacting protein 1 | Often (30–79%) | In 1 condition |
| BBS10Bardet-Biedl syndrome 10 | Often (30–79%) | In 1 condition |
| BBS12Bardet-Biedl syndrome 12 | Often (30–79%) | In 1 condition |
| BBS7Bardet-Biedl syndrome 7 | Often (30–79%) | In 1 condition |
| BBS9Bardet-Biedl syndrome 9 | Often (30–79%) | In 1 condition |
| BEST1bestrophin 1 | Often (30–79%) | In 3 conditions |
| C1QTNF5C1q and TNF related 5 | Often (30–79%) | In 1 condition |
| CA4carbonic anhydrase 4 | Often (30–79%) | In 1 condition |
| CABP4calcium binding protein 4 | Often (30–79%) | In 1 condition |
| CC2D2Acoiled-coil and C2 domain containing 2A | Often (30–79%) | In 1 condition |
| CEP19centrosomal protein 19 | Often (30–79%) | In 1 condition |
| CEP290centrosomal protein 290 | Often (30–79%) | In 1 condition |
| CERKLCERK like autophagy regulator | Often (30–79%) | In 1 condition |
| CNNM4cyclin and CBS domain divalent metal cation transport mediator 4 | Often (30–79%) | In 1 condition |
| COG4component of oligomeric golgi complex 4 | Often (30–79%) | In 1 condition |
| COL8A2collagen type VIII alpha 2 chain | Often (30–79%) | In 1 condition |
| COQ8Bcoenzyme Q8B | Often (30–79%) | In 1 condition |
| CRB1crumbs cell polarity complex component 1 | Often (30–79%) | In 2 conditions |
| CYP4V2cytochrome P450 family 4 subfamily V member 2 | Often (30–79%) | In 1 condition |
| EXOSC2exosome component 2 | Often (30–79%) | In 1 condition |
| EYSEGF-like photoreceptor maintenance factor | Often (30–79%) | In 2 conditions |
| FAM161AFAM161 centrosomal protein A | Often (30–79%) | In 2 conditions |
| FDXRferredoxin reductase | Often (30–79%) | In 1 condition |
| FLVCR1FLVCR choline and heme transporter 1 | Often (30–79%) | In 2 conditions |
| FSCN2fascin actin-bundling protein 2, retinal | Often (30–79%) | In 2 conditions |
| GNB3G protein subunit beta 3 | Often (30–79%) | In 1 condition |
| GNSglucosamine (N-acetyl)-6-sulfatase | Often (30–79%) | In 1 condition |
| GUCA1Bguanylate cyclase activator 1B | Often (30–79%) | In 1 condition |
| IDH3Bisocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta | Often (30–79%) | In 1 condition |
| IFT27intraflagellar transport 27 | Often (30–79%) | In 1 condition |
| IFT74intraflagellar transport 74 | Often (30–79%) | In 1 condition |
| IFT88intraflagellar transport 88 | Often (30–79%) | In 1 condition |
| IMPG1interphotoreceptor matrix proteoglycan 1 | Often (30–79%) | In 1 condition |
| IMPG2interphotoreceptor matrix proteoglycan 2 | Often (30–79%) | In 2 conditions |
| KCNJ13potassium inwardly rectifying channel subfamily J member 13 | Often (30–79%) | In 2 conditions |
| KLHL7kelch like family member 7 | Often (30–79%) | In 1 condition |
| LCA5lebercilin LCA5 | Often (30–79%) | In 1 condition |
| LRATlecithin retinol acyltransferase | Often (30–79%) | In 4 conditions |
| LZTFL1leucine zipper transcription factor like 1 | Often (30–79%) | In 1 condition |
| MKKSMKKS centrosomal shuttling protein | Often (30–79%) | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Often (30–79%) | In 1 condition |
| MTTPmicrosomal triglyceride transfer protein | Often (30–79%) | In 1 condition |
| NEK2NIMA related kinase 2 | Often (30–79%) | In 1 condition |
| NPHP1nephrocystin 1 | Often (30–79%) | In 1 condition |
| OFD1OFD1 centriole and centriolar satellite protein | Often (30–79%) | In 1 condition |
| OTX2orthodenticle homeobox 2 | Often (30–79%) | In 1 condition |
| PCAREphotoreceptor cilium actin regulator | Often (30–79%) | In 2 conditions |
| PDE6Gphosphodiesterase 6G | Often (30–79%) | In 2 conditions |
| PDZD7PDZ domain containing 7 | Often (30–79%) | In 1 condition |
| PHYHphytanoyl-CoA 2-hydroxylase | Often (30–79%) | In 2 conditions |
| PRCDphotoreceptor disc component | Often (30–79%) | In 1 condition |
| PRPF3pre-mRNA processing factor 3 | Often (30–79%) | In 2 conditions |
| RBP3retinol binding protein 3 | Often (30–79%) | In 3 conditions |
| RDH12retinol dehydrogenase 12 | Often (30–79%) | In 1 condition |
| RGRretinal G protein coupled receptor | Often (30–79%) | In 1 condition |
| RNU4-2RNA, U4 small nuclear 2 | Often (30–79%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 1 condition |
| RNU6-1RNA, U6 small nuclear 1 | Often (30–79%) | In 1 condition |
| RNU6-2RNA, U6 small nuclear 2 | Often (30–79%) | In 1 condition |
| RNU6-8RNA, U6 small nuclear 8 | Often (30–79%) | In 1 condition |
| RNU6-9RNA, U6 small nuclear 9 | Often (30–79%) | In 1 condition |
| ROM1retinal outer segment membrane protein 1 | Often (30–79%) | In 3 conditions |
| RP2RP2 activator of ARL3 GTPase | Often (30–79%) | In 2 conditions |
| RP9RP9 pre-mRNA splicing factor | Often (30–79%) | In 2 conditions |
| SAGS-antigen visual arrestin | Often (30–79%) | In 2 conditions |
| SAXO6stabilizer of axonemal microtubules 6 | Often (30–79%) | In 1 condition |
| SCLT1sodium channel and clathrin linker 1 | Often (30–79%) | In 1 condition |
| SDCCAG8SHH signaling and ciliogenesis regulator SDCCAG8 | Often (30–79%) | In 1 condition |
| SLC4A11solute carrier family 4 member 11 | Often (30–79%) | In 1 condition |
| SNRNP200small nuclear ribonucleoprotein U5 subunit 200 | Often (30–79%) | In 2 conditions |
| SPATA7spermatogenesis associated 7 | Often (30–79%) | In 3 conditions |
| TCF4transcription factor 4 | Often (30–79%) | In 1 condition |
| TIMP3TIMP metallopeptidase inhibitor 3 | Often (30–79%) | In 1 condition |
| TOPORSTOP1 binding arginine/serine rich protein, E3 ubiquitin ligase | Often (30–79%) | In 1 condition |
| TRIM32tripartite motif containing 32 | Often (30–79%) | In 1 condition |
| TTC8tetratricopeptide repeat domain 8 | Often (30–79%) | In 3 conditions |
| TTPAalpha tocopherol transfer protein | Often (30–79%) | In 1 condition |
| TUBTUB bipartite transcription factor | Often (30–79%) | In 1 condition |
| USH2Ausherin | Often (30–79%) | In 2 conditions |
| VCANversican | Often (30–79%) | In 1 condition |
| WDPCPWD repeat containing planar cell polarity effector | Often (30–79%) | In 1 condition |
| WDR19WD repeat domain 19 | Often (30–79%) | In 1 condition |
| ZEB1zinc finger E-box binding homeobox 1 | Often (30–79%) | In 1 condition |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Sometimes (5–29%) | In 1 condition |
| HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Sometimes (5–29%) | In 1 condition |
| ITM2Bintegral membrane protein 2B | Sometimes (5–29%) | In 1 condition |
| LAMP2lysosome associated membrane protein 2 | Sometimes (5–29%) | In 1 condition |
| MMP19matrix metallopeptidase 19 | Sometimes (5–29%) | In 1 condition |
| RS1retinoschisin 1 | Sometimes (5–29%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Sometimes (5–29%) | In 1 condition |
| ZPR1ZPR1 zinc finger | Sometimes (5–29%) | In 1 condition |
| ACBD6acyl-CoA binding domain containing 6 | Rarely (1–4%) | In 1 condition |
| MFN2mitofusin 2 | Rarely (1–4%) | In 1 condition |
| CLCC1chloride channel CLIC like 1 | Not recorded | In 1 condition |
| HK1hexokinase 1 | Not recorded | In 1 condition |
| INPP5Einositol polyphosphate-5-phosphatase E | Not recorded | In 1 condition |
| KCNV2potassium voltage-gated channel modifier subfamily V member 2 | Not recorded | In 1 condition |
| KIF3Bkinesin family member 3B | Not recorded | In 1 condition |
| MVKmevalonate kinase | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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