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Gene

ARHGEF18

Rho/Rac guanine nucleotide exchange factor 18

Summary

Cytogenetic location
19p13.2
Coordinates
Chromosome 19: 7,348,937–7,472,478 (GRCh38)
Exons
29 exons across 123.5 kb
Protein
1,361 amino acids
Also known as
P114-RhoGEF, KIAA0521, MGC15913, p114RhoGEF
MANE Select transcript
ENST00000668164.2NM_001367823.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Retinitis Pigmentosa

      • One of 77 genes linked to it

        A group of inherited retinal dystrophies with progressive loss of rod and then cone photoreceptors, causing night blindness and gradual loss of peripheral vision.

        • 2 GenCC submitters rate it definitive or strong

    How ARHGEF18 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 19, with a bracket where ARHGEF18 sits. ARHGEF18 and 34 genes near it on chromosome 19, from 6,910,708 to 7,910,707.Chromosome 1919p13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.437 Mb7.2 Mb7.4 Mb7.6 Mb7.8 MbADGRE1: 6,887,530–6,940,459, forward strandADGRE1MBD3L2B: 7,018,969–7,021,431, reverse strandMBD3L5: 7,030,578–7,033,011, forward strandMBD3L4: 7,037,749–7,040,179, reverse strandMBD3L4MBD3L2: 7,049,321–7,051,735, forward strandMBD3L2MBD3L3: 7,056,207–7,069,665, reverse strandMBD3L3ZNF557: 7,069,416–7,096,206, forward strandZNF557INSR: 7,112,255–7,294,443, reverse strandINSRARHGEF18: 7,348,937–7,472,478, forward strandARHGEF18PEX11G: 7,476,869–7,497,449, reverse strandPEX11GSAXO5: 7,492,976–7,509,030, forward strandSAXO5: 7,507,052–7,519,622, forward strandZNF358: 7,515,292–7,521,027, forward strandZNF358MCOLN1: 7,522,611–7,534,009, forward strand: 7,533,595–7,540,059, forward strandPNPLA6: 7,534,004–7,561,764, forward strandCAMSAP3: 7,595,826–7,618,352, forward strandCAMSAP3XAB2: 7,619,523–7,629,573, reverse strandXAB2PET100: 7,629,711–7,631,956, forward strandPET100: 7,629,796–7,647,477, forward strandPCP2: 7,631,611–7,635,831, reverse strandPCP2STXBP2: 7,636,772–7,647,875, forward strandRETN: 7,669,044–7,670,456, forward strandMCEMP1: 7,677,056–7,679,834, forward strand: 7,678,501–7,682,854, forward strandTRAPPC5: 7,680,823–7,687,703, forward strandFCER2: 7,688,758–7,702,146, reverse strandFCER2CLEC4G: 7,728,943–7,733,906, reverse strandCLEC4G: 7,728,958–7,745,662, reverse strandCD209: 7,739,993–7,747,623, reverse strandCD209CLEC4M: 7,763,031–7,769,606, forward strandCLEC4MEVI5L: 7,830,182–7,864,980, forward strandEVI5LPRR36: 7,868,719–7,874,674, reverse strandPRR36LRRC8E: 7,888,500–7,902,021, forward strandLRRC8EMAP2K7: 7,903,823–7,914,480, forward strandMAP2K7Diagram of ARHGEF18: 29 exons on the forward strand of chromosome 19Exon 3: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 1: 7,348,937–7,349,241, 305 basesExon 2: 7,362,781–7,362,905, 125 basesExon 3: 7,372,812–7,373,071, 260 basesExon 4: 7,375,720–7,375,870, 151 basesExon 5: 7,376,643–7,376,757, 115 basesExon 6: 7,378,394–7,378,451, 58 basesExon 7: 7,379,122–7,379,166, 45 basesExon 8: 7,380,917–7,380,994, 78 basesExon 9: 7,382,792–7,382,894, 103 basesExon 10: 7,383,062–7,383,203, 142 basesExon 11: 7,440,344–7,440,482, 139 basesExon 12: 7,441,653–7,441,765, 113 basesExon 13: 7,441,912–7,442,052, 141 basesExon 14: 7,444,204–7,444,454, 251 basesExon 15: 7,447,043–7,447,168, 126 basesExon 16: 7,451,149–7,451,266, 118 basesExon 17: 7,453,467–7,453,715, 249 basesExon 18: 7,456,327–7,456,403, 77 basesExon 19: 7,458,512–7,458,690, 179 basesExon 20: 7,459,903–7,459,994, 92 basesExon 21: 7,462,152–7,462,334, 183 basesExon 22: 7,463,818–7,463,955, 138 basesExon 23: 7,464,560–7,464,690, 131 basesExon 24: 7,466,918–7,466,974, 57 basesExon 25: 7,467,071–7,467,118, 48 basesExon 26: 7,467,214–7,467,684, 471 basesExon 27: 7,468,825–7,469,131, 307 basesExon 28: 7,469,904–7,470,029, 126 basesExon 29: 7,470,126–7,472,478, 2,353 bases1510152025295′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.7 kb of the gene's 123.5 kb; 4,086 of those bases code for the protein.

    How a genome test reads ARHGEF18

    5

    positions in ARHGEF18 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 123.5 kb of ARHGEF18, introns included, not only the 6.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ARHGEF18 gene: Rho/Rac guanine nucleotide exchange factor 18. Retrieved 17 October 2026, from https://dantelabs.com/genes/arhgef18

    Vancouver

    Dante Labs. ARHGEF18 gene: Rho/Rac guanine nucleotide exchange factor 18 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arhgef18

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