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Gene

CACNA2D4

calcium voltage-gated channel auxiliary subunit alpha2delta 4

Summary

Cytogenetic location
12p13.33
Coordinates
Chromosome 12: 1,791,963–1,918,652 (GRCh38)
Exons
38 exons across 126.7 kb
Protein
1,137 amino acids
Also known as
alpha2delta-4
MANE Select transcript
ENST00000382722.10NM_172364.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CACNA2D4 yet. The test sequences your whole genome, so your data includes it all the same.

How CACNA2D4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where CACNA2D4 sits. CACNA2D4 and 7 genes near it on chromosome 12, from 1,355,308 to 2,355,307.Chromosome 1212p13.33p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.331.4 Mb1.6 Mb1.8 Mb2 Mb2.2 MbERC1: 989,998–1,495,933, forward strandERC1WNT5B: 1,529,854–1,647,243, forward strandWNT5BFBXL14: 1,561,841–1,594,853, reverse strandFBXL14ADIPOR2: 1,688,574–1,788,683, forward strandADIPOR2CACNA2D4: 1,791,963–1,918,652, reverse strandCACNA2D4LRTM2: 1,820,267–1,836,753, forward strandLRTM2DCP1B: 1,939,625–2,004,558, reverse strandDCP1BCACNA1C: 1,970,690–2,697,950, forward strandCACNA1CDiagram of CACNA2D4: 38 exons on the reverse strand of chromosome 12Exon 33: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 38: 1,791,963–1,793,759, 1,797 basesExon 37: 1,795,299–1,795,381, 83 basesExon 36: 1,795,668–1,795,780, 113 basesExon 35: 1,797,418–1,797,535, 118 basesExon 34: 1,799,675–1,799,695, 21 basesExon 33: 1,800,000–1,800,052, 53 basesExon 32: 1,800,386–1,800,438, 53 basesExon 31: 1,801,043–1,801,118, 76 basesExon 30: 1,801,574–1,801,644, 71 basesExon 29: 1,810,278–1,810,340, 63 basesExon 28: 1,810,543–1,810,587, 45 basesExon 27: 1,811,662–1,811,723, 62 basesExon 26: 1,840,739–1,840,819, 81 basesExon 25: 1,844,402–1,844,529, 128 basesExon 24: 1,846,594–1,846,689, 96 basesExon 23: 1,853,951–1,854,044, 94 basesExon 22: 1,856,012–1,856,109, 98 basesExon 21: 1,856,184–1,856,229, 46 basesExon 20: 1,858,577–1,858,644, 68 basesExon 19: 1,860,145–1,860,206, 62 basesExon 18: 1,874,604–1,874,675, 72 basesExon 17: 1,875,251–1,875,337, 87 basesExon 16: 1,878,315–1,878,389, 75 basesExon 15: 1,878,956–1,879,036, 81 basesExon 14: 1,879,804–1,879,881, 78 basesExon 13: 1,882,867–1,883,000, 134 basesExon 12: 1,884,243–1,884,321, 79 basesExon 11: 1,884,768–1,884,881, 114 basesExon 10: 1,884,987–1,885,076, 90 basesExon 9: 1,885,965–1,886,039, 75 basesExon 8: 1,886,223–1,886,373, 151 basesExon 7: 1,887,009–1,887,069, 61 basesExon 6: 1,907,440–1,907,571, 132 basesExon 5: 1,907,875–1,908,037, 163 basesExon 4: 1,909,906–1,909,965, 60 basesExon 3: 1,913,023–1,913,139, 117 basesExon 2: 1,914,854–1,914,935, 82 basesExon 1: 1,918,247–1,918,652, 406 bases38353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.3 kb of the gene's 126.7 kb; 3,414 of those bases code for the protein.

How a genome test reads CACNA2D4

8

positions in CACNA2D4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 126.7 kb of CACNA2D4, introns included, not only the 5.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CACNA2D4 gene: calcium voltage-gated channel auxiliary subunit alpha2delta 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/cacna2d4

Vancouver

Dante Labs. CACNA2D4 gene: calcium voltage-gated channel auxiliary subunit alpha2delta 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cacna2d4

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