Skip to content
Use your HSA or FSA funds

Gene

NEK2

NIMA related kinase 2

Summary

Cytogenetic location
1q32.3
Coordinates
Chromosome 1: 211,662,772–211,675,621 (GRCh38)
Exons
8 exons across 12.9 kb
Protein
445 amino acids
Also known as
NLK1, NEK2A, RP67, PPP1R111
MANE Select transcript
ENST00000366999.9NM_002497.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads NEK2 yet. The test sequences your whole genome, so your data includes it all the same.

How NEK2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where NEK2 sits. NEK2 and 8 genes near it on chromosome 1, from 211,169,197 to 212,169,196.Chromosome 11q32.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44211.2 Mb211.4 Mb211.6 Mb211.8 Mb212 Mb: 211,082,872–211,188,533, reverse strandRCOR3: 211,258,377–211,316,385, forward strandRCOR3TRAF5: 211,326,325–211,375,117, forward strandTRAF5RD3: 211,476,522–211,492,490, reverse strandRD3SLC30A1: 211,571,568–211,579,218, reverse strandSLC30A1NEK2: 211,662,772–211,675,621, reverse strandNEK2LPGAT1: 211,743,457–211,833,674, reverse strandLPGAT1INTS7: 211,940,317–212,035,572, reverse strandINTS7DTL: 212,035,553–212,107,400, forward strandDTLDiagram of NEK2: 8 exons on the reverse strand of chromosome 1Exon 8: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 8: 211,662,772–211,663,652, 881 basesExon 7: 211,667,106–211,667,231, 126 basesExon 6: 211,669,113–211,669,332, 220 basesExon 5: 211,670,281–211,670,407, 127 basesExon 4: 211,671,202–211,671,284, 83 basesExon 3: 211,673,483–211,673,723, 241 basesExon 2: 211,674,296–211,674,513, 218 basesExon 1: 211,675,384–211,675,621, 238 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 12.9 kb; 1,338 of those bases code for the protein.

How a genome test reads NEK2

6

positions in NEK2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 12.9 kb of NEK2, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NEK2 gene: NIMA related kinase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/nek2

Vancouver

Dante Labs. NEK2 gene: NIMA related kinase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nek2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test