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Gene

GNB3

G protein subunit beta 3

Summary

Cytogenetic location
12p13.31
Coordinates
Chromosome 12: 6,840,925–6,847,393 (GRCh38)
Exons
10 exons across 6.5 kb
Protein
340 amino acids
MANE Select transcript
ENST00000229264.8NM_002075.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Stationary Night Blindness

    • A group of mostly non-progressive retinal conditions, including Oguchi disease, caused by changes in genes such as NYX, CACNA1F, TRPM1, GRM6, GPR179 and SAG, often with nystagmus or short-sightedness.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      A genetic diagnosis explains the symptoms, helps distinguish the condition from progressive retinal diseases and informs family counselling.

How GNB3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 12, with a bracket where GNB3 sits. GNB3 and 45 genes near it on chromosome 12, from 6,344,159 to 7,344,158.Chromosome 1212p13.31p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.336.4 Mb6.6 Mb6.8 Mb7 Mb7.2 MbSCNN1A: 6,345,124–6,383,917, reverse strandSCNN1ALTBR: 6,375,045–6,391,571, forward strandLTBRCD27: 6,444,933–6,451,718, forward strandCD27TAPBPL: 6,451,690–6,466,517, forward strandTAPBPLVAMP1: 6,462,237–6,470,948, reverse strandVAMP1MRPL51: 6,490,204–6,493,856, reverse strandMRPL51NCAPD2: 6,493,356–6,531,970, forward strandNCAPD2GAPDH: 6,534,012–6,538,930, forward strandGAPDHIFFO1: 6,538,961–6,556,102, reverse strandIFFO1NOP2: 6,556,863–6,568,691, reverse strandNOP2: 6,556,886–6,607,367, reverse strandCHD4: 6,570,081–6,614,982, reverse strandCHD4LPAR5: 6,618,835–6,636,444, reverse strandLPAR5ACRBP: 6,638,075–6,647,441, reverse strandACRBPING4: 6,650,282–6,663,180, reverse strandING4ZNF384: 6,665,037–6,689,572, reverse strandZNF384PIANP: 6,693,791–6,700,859, reverse strandPIANPCOPS7A: 6,724,014–6,732,462, forward strandCOPS7AMLF2: 6,747,986–6,768,932, reverse strandMLF2PTMS: 6,765,516–6,770,952, forward strandPTMSLAG3: 6,772,360–6,778,455, forward strandLAG3CD4: 6,786,858–6,820,807, forward strandGPR162: 6,821,624–6,829,972, forward strandP3H3: 6,828,220–6,839,867, forward strandP3H3GNB3: 6,840,925–6,847,393, forward strandGNB3CDCA3: 6,844,723–6,852,353, reverse strandCDCA3USP5: 6,852,098–6,866,632, forward strandUSP5TPI1: 6,867,119–6,878,513, forward strandSPSB2: 6,870,934–6,889,358, reverse strandLRRC23: 6,873,455–6,914,243, forward strandLRRC23ENO2: 6,913,745–6,923,970, forward strandENO2ATN1: 6,924,454–6,942,322, forward strandATN1C12orf57: 6,942,919–6,946,009, forward strandRNU7-1: 6,943,816–6,943,878, forward strandRNU7-1PTPN6: 6,946,417–6,961,316, forward strandPTPN6PHB2: 6,965,327–6,970,841, reverse strandEMG1: 6,970,765–6,979,939, forward strand: 6,970,921–6,997,428, forward strandLPCAT3: 6,972,027–7,018,779, reverse strandC1S: 6,988,259–7,071,281, forward strandC1SC1R: 7,080,213–7,092,873, reverse strandC1RC1RL: 7,089,587–7,109,245, reverse strandC1RLRBP5: 7,115,736–7,128,891, reverse strandRBP5CLSTN3: 7,128,077–7,158,945, forward strandCLSTN3PEX5: 7,188,653–7,218,574, forward strandPEX5ACSM4: 7,304,072–7,328,719, forward strandACSM4Diagram of GNB3: 10 exons on the forward strand of chromosome 12Exon 1: 6,840,925–6,841,033, 109 basesExon 2: 6,841,258–6,841,344, 87 basesExon 3: 6,841,586–6,841,624, 39 basesExon 4: 6,842,970–6,843,076, 107 basesExon 5: 6,843,174–6,843,237, 64 basesExon 6: 6,843,363–6,843,525, 163 basesExon 7: 6,843,632–6,843,698, 67 basesExon 8: 6,843,777–6,843,978, 202 basesExon 9: 6,845,586–6,845,802, 217 basesExon 10: 6,846,792–6,847,393, 602 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 6.5 kb; 1,023 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GNB3 gene: G protein subunit beta 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/gnb3

Vancouver

Dante Labs. GNB3 gene: G protein subunit beta 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/gnb3

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