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Gene

RAX2

retina and anterior neural fold homeobox 2

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 3,769,089–3,772,228 (GRCh38)
Exons
3 exons across 3.1 kb
Protein
184 amino acids
Also known as
MGC15631, ARMD6, CORD11
Previous symbols
RAXL1
MANE Select transcript
ENST00000555633.3NM_001319074.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Retinitis Pigmentosa

      • One of 77 genes linked to it

        A group of inherited retinal dystrophies with progressive loss of rod and then cone photoreceptors, causing night blindness and gradual loss of peripheral vision.

        • 2 GenCC submitters rate it definitive or strong

    How RAX2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome 19, with a bracket where RAX2 sits. RAX2 and 30 genes near it on chromosome 19, from 3,270,659 to 4,270,658.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.433.4 Mb3.6 Mb3.8 Mb4 Mb4.2 MbCELF5: 3,224,636–3,297,076, forward strandCELF5NFIC: 3,314,403–3,469,217, forward strandNFICSMIM24: 3,473,986–3,480,557, reverse strandSMIM24SMIM44: 3,482,110–3,483,441, reverse strandSMIM44DOHH: 3,490,821–3,507,203, reverse strandDOHHFZR1: 3,506,270–3,538,334, forward strandFZR1MFSD12: 3,538,261–3,574,290, reverse strandMFSD12TEKTIP1: 3,539,169–3,544,030, forward strandHMG20B: 3,572,692–3,579,088, forward strandHMG20BGIPC3: 3,585,474–3,593,541, forward strandGIPC3TBXA2R: 3,594,506–3,606,900, reverse strandTBXA2RCACTIN: 3,610,643–3,626,833, reverse strandCACTINPIP5K1C: 3,630,181–3,700,506, reverse strandPIP5K1CTJP3: 3,708,310–3,750,813, forward strandTJP3APBA3: 3,750,772–3,761,700, reverse strandAPBA3MRPL54: 3,761,841–3,769,033, forward strandMRPL54RAX2: 3,769,089–3,772,228, reverse strandRAX2MATK: 3,777,969–3,802,129, reverse strandMATKZFR2: 3,804,024–3,869,055, reverse strandZFR2ATCAY: 3,879,864–3,928,082, forward strandATCAYNMRK2: 3,932,994–3,943,081, forward strandNMRK2DAPK3: 3,958,453–3,971,130, reverse strandDAPK3EEF2: 3,976,044–3,985,479, reverse strandEEF2PIAS4: 4,007,690–4,039,386, forward strandPIAS4ZBTB7A: 4,041,419–4,067,636, reverse strandZBTB7AMAP2K2: 4,090,316–4,124,238, reverse strandMAP2K2CREB3L3: 4,152,949–4,173,057, forward strandCREB3L3SIRT6: 4,174,104–4,182,604, reverse strandSIRT6ANKRD24: 4,182,630–4,224,818, forward strandANKRD24EBI3: 4,229,267–4,238,167, forward strandEBI3YJU2: 4,247,062–4,269,091, forward strandYJU2Diagram of RAX2: 3 exons on the reverse strand of chromosome 19Exon 3: 2 known disease-causing sitesExon 3: 3,769,089–3,770,959, 1,871 basesExon 2: 3,771,527–3,772,010, 484 basesExon 1: 3,772,163–3,772,228, 66 bases3215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.4 kb of the gene's 3.1 kb; 555 of those bases code for the protein.

    How a genome test reads RAX2

    3

    positions in RAX2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 3.1 kb of RAX2, introns included, not only the 2.4 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). RAX2 gene: retina and anterior neural fold homeobox 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/rax2

    Vancouver

    Dante Labs. RAX2 gene: retina and anterior neural fold homeobox 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rax2

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