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Gene

RIMS1

regulating synaptic membrane exocytosis 1

Summary

Cytogenetic location
6q13
Coordinates
Chromosome 6: 71,886,550–72,403,145 (GRCh38)
Exons
34 exons across 516.6 kb
Protein
1,692 amino acids
Also known as
RIM, KIAA0340, RIM1
Previous symbols
RAB3IP2, CORD7
MANE Select transcript
ENST00000521978.6NM_014989.7
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Autism Spectrum Disorder

    • A spectrum of developmental disorders that includes autism, and Asperger syndrome. Signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Early intervention services, behavioral therapy, speech and occupational therapy, psychopharmacology for associated features

How RIMS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where RIMS1 sits. RIMS1 and 1 gene near it on chromosome 6, from 71,369,954 to 72,919,741.Chromosome 66q13p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2771.4 Mb71.6 Mb71.8 Mb72 Mb72.2 Mb72.4 Mb72.6 Mb72.8 MbRIMS1: 71,886,550–72,403,145, forward strandRIMS1KCNQ5: 72,621,623–73,198,853, forward strandKCNQ5Diagram of RIMS1: 34 exons on the forward strand of chromosome 6Exon 1: 71,886,550–71,887,187, 638 basesExon 2: 71,968,983–71,969,063, 81 basesExon 3: 72,096,949–72,097,162, 214 basesExon 4: 72,099,975–72,099,986, 12 basesExon 5: 72,179,575–72,179,915, 341 basesExon 6: 72,182,284–72,183,149, 866 basesExon 7: 72,233,773–72,233,840, 68 basesExon 8: 72,235,618–72,235,728, 111 basesExon 9: 72,237,823–72,237,922, 100 basesExon 10: 72,242,314–72,242,437, 124 basesExon 11: 72,245,815–72,245,861, 47 basesExon 12: 72,248,015–72,248,127, 113 basesExon 13: 72,250,330–72,250,460, 131 basesExon 14: 72,250,921–72,251,092, 172 basesExon 15: 72,251,215–72,251,368, 154 basesExon 16: 72,252,761–72,252,832, 72 basesExon 17: 72,258,125–72,258,281, 157 basesExon 18: 72,258,986–72,259,111, 126 basesExon 19: 72,260,705–72,260,767, 63 basesExon 20: 72,264,975–72,265,052, 78 basesExon 21: 72,265,390–72,265,503, 114 basesExon 22: 72,265,960–72,266,049, 90 basesExon 23: 72,274,349–72,274,432, 84 basesExon 24: 72,284,047–72,284,118, 72 basesExon 25: 72,290,679–72,290,861, 183 basesExon 26: 72,291,934–72,292,046, 113 basesExon 27: 72,307,258–72,307,370, 113 basesExon 28: 72,313,506–72,313,672, 167 basesExon 29: 72,333,600–72,333,835, 236 basesExon 30: 72,390,598–72,390,736, 139 basesExon 31: 72,392,698–72,392,810, 113 basesExon 32: 72,398,249–72,398,350, 102 basesExon 33: 72,398,955–72,399,094, 140 basesExon 34: 72,400,496–72,403,145, 2,650 bases120345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8 kb of the gene's 516.6 kb; 5,079 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RIMS1 gene: regulating synaptic membrane exocytosis 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/rims1

Vancouver

Dante Labs. RIMS1 gene: regulating synaptic membrane exocytosis 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rims1

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