Gene
SLC30A2
solute carrier family 30 member 2
- HGNC 11013(opens in a new tab)
- Ensembl gene ENSG00000158014(opens in a new tab)
- NCBI Gene 7780(opens in a new tab)
Summary
- Cytogenetic location
- 1p36.11
- Coordinates
- Chromosome 1: 26,037,252–26,046,118 (GRCh38)
- Exons
- 8 exons across 8.9 kb
- Protein
- 372 amino acids
- Inheritance
- Autosomal dominant
- Previous symbols
- ZNT2
- MANE Select transcript
- ENST00000374276.4NM_001004434.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Acrodermatitis Enteropathica
- Transient Neonatal Zinc DeficiencyAutosomal dominant
Zinc deficiency in breastfed infants caused by SLC30A2 variants in the mother that reduce zinc in breast milk; the variant is found in the mother, not the infant, and the infant's symptoms resemble acrodermatitis enteropathica.
- ClinGen rates the link definitive
- 2 GenCC submitters rate it definitive or strong
What knowing changes
Knowing allows zinc supplementation for affected infants and planning for future breastfed children.
Inheritance
- Autosomal dominant
- One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
How SLC30A2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.2 kb of the gene's 8.9 kb; 1,119 of those bases code for the protein.
How a genome test reads SLC30A2
2
positions in SLC30A2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 8.9 kb of SLC30A2, introns included, not only the 3.2 kb of exons.
Traits linked to SLC30A2
The Human Phenotype Ontology lists these as features of the rare conditions SLC30A2 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). SLC30A2 gene: solute carrier family 30 member 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc30a2
Dante Labs. SLC30A2 gene: solute carrier family 30 member 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc30a2
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