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Gene

PIK3CG

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Summary

Cytogenetic location
7q22.3
Coordinates
Chromosome 7: 106,865,282–106,908,980 (GRCh38)
Exons
11 exons across 43.7 kb
Protein
1,102 amino acids
MANE Select transcript
ENST00000496166.6NM_001282426.2
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • ClinGen rates the link moderate
        • 1 GenCC submitter rates it definitive or strong
        Actionability

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How PIK3CG is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Stretches short reads find hard
    Chromosome 7, with a bracket where PIK3CG sits. PIK3CG and 4 genes near it on chromosome 7, from 106,387,131 to 107,387,130.Chromosome 77q22.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3106.4 Mb106.6 Mb106.8 Mb107 Mb107.2 MbCCDC71L: 106,654,360–106,661,158, reverse strandCCDC71LPIK3CG: 106,865,282–106,908,980, forward strandPIK3CGPRKAR2B: 107,044,627–107,161,811, forward strandPRKAR2BHBP1: 107,168,961–107,202,529, forward strandHBP1COG5: 107,198,800–107,564,515, reverse strandCOG5Diagram of PIK3CG: 11 exons on the forward strand of chromosome 7Exon 1: 106,865,282–106,865,426, 145 basesExon 2: 106,867,550–106,869,556, 2,007 basesExon 3: 106,872,537–106,872,602, 66 basesExon 4: 106,872,713–106,872,938, 226 basesExon 5: 106,874,700–106,874,803, 104 basesExon 6: 106,879,519–106,879,665, 147 basesExon 7: 106,882,117–106,882,207, 91 basesExon 8: 106,883,033–106,883,163, 131 basesExon 9: 106,884,155–106,884,266, 112 basesExon 10: 106,886,135–106,886,292, 158 basesExon 11: 106,905,109–106,908,980, 3,872 bases1246810115′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 7.1 kb of the gene's 43.7 kb; 3,309 of those bases code for the protein.

    Genes linked to the same conditions

    Traits linked to PIK3CG

    The Human Phenotype Ontology lists these as features of the rare conditions PIK3CG can cause. Each trait's page lists the other genes linked to it.

    External links

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.17-8666dff2.

    Cite this page

    APA

    Dante Labs. (n.d.). PIK3CG gene: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma. Retrieved 17 October 2026, from https://dantelabs.com/genes/pik3cg

    Vancouver

    Dante Labs. PIK3CG gene: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pik3cg

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