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Gene

MSN

moesin

Summary

Cytogenetic location
Xq12
Coordinates
Chromosome X: 65,667,654–65,741,931 (GRCh38)
Exons
13 exons across 74.3 kb
Protein
577 amino acids
MANE Select transcript
ENST00000360270.7NM_002444.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Inborn error of immunity

        One of 114 genes linked to it

        Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong
      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How MSN is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome X, with a bracket where MSN sits. MSN and 4 genes near it on chromosome X, from 65,204,793 to 66,204,792.Chromosome XXq12p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2865.4 Mb65.6 Mb65.8 Mb66 Mb66.2 MbZC3H12B: 65,034,788–65,507,887, forward strandZC3H12BLAS1L: 65,438,549–65,534,818, reverse strandLAS1LMSN: 65,667,654–65,741,931, forward strandMSNVSIG4: 66,021,738–66,040,146, reverse strandVSIG4HEPH: 66,162,483–66,268,910, forward strandHEPHDiagram of MSN: 13 exons on the forward strand of chromosome XExon 5: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 1: 65,667,654–65,667,853, 200 basesExon 2: 65,716,818–65,716,901, 84 basesExon 3: 65,727,814–65,727,909, 96 basesExon 4: 65,729,438–65,729,712, 275 basesExon 5: 65,731,107–65,731,190, 84 basesExon 6: 65,731,838–65,731,984, 147 basesExon 7: 65,733,184–65,733,280, 97 basesExon 8: 65,735,267–65,735,430, 164 basesExon 9: 65,736,795–65,736,925, 131 basesExon 10: 65,737,178–65,737,338, 161 basesExon 11: 65,738,525–65,738,617, 93 basesExon 12: 65,738,970–65,739,194, 225 basesExon 13: 65,739,729–65,741,931, 2,203 bases124681012135′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4 kb of the gene's 74.3 kb; 1,734 of those bases code for the protein.

    How a genome test reads MSN

    2

    positions in MSN where ClinVar classes a change as pathogenic or likely pathogenic

    1 of them (50%) falls in a region short reads find hard.

    • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

    A whole genome covers all 74.3 kb of MSN, introns included, not only the 4 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). MSN gene: moesin. Retrieved 17 October 2026, from https://dantelabs.com/genes/msn

    Vancouver

    Dante Labs. MSN gene: moesin [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/msn

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