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Gene

SLC39A7

solute carrier family 39 member 7

Summary

Cytogenetic location
6p21.32
Coordinates
Chromosome 6: 33,200,867–33,204,437 (GRCh38)
Exons
7 exons across 3.6 kb
Protein
469 amino acids
Inheritance
Autosomal recessive
Also known as
H2-KE4, D6S2244E, KE4, RING5, ZIP7
Previous symbols
HKE4
MANE Select transcript
ENST00000374677.8NM_006979.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Agammaglobulinaemia (XLA and Autosomal Forms)

    • Agammaglobulinaemia 9 (SLC39A7)Autosomal recessive

      Absent B cells and antibody deficiency caused by changes in the zinc transporter gene SLC39A7.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Lifelong immunoglobulin replacement, prompt treatment of infections and avoiding live vaccines prevent most serious complications.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • 2 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SLC39A7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where SLC39A7 sits. SLC39A7 and 38 genes near it on chromosome 6, from 32,702,652 to 33,702,651.Chromosome 66p21.32p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2732.8 Mb33 Mb33.2 Mb33.4 Mb33.6 MbHLA-DQA2: 32,741,391–32,747,198, forward strandHLA-DQA2HLA-DQB2: 32,756,094–32,763,563, reverse strandHLA-DQB2HLA-DOB: 32,812,763–32,820,466, reverse strand: 32,813,767–32,838,822, reverse strandTAP2: 32,821,833–32,838,802, reverse strandTAP2PSMB8: 32,840,717–32,844,679, reverse strandPSMB8PSMB9: 32,844,136–32,882,881, forward strandPSMB9TAP1: 32,845,204–32,854,026, reverse strandTAP1HLA-DMB: 32,929,338–32,941,490, reverse strandHLA-DMB: 32,937,364–32,953,122, reverse strandHLA-DMA: 32,948,613–32,969,094, reverse strandHLA-DMABRD2: 32,968,564–32,981,505, forward strandBRD2HLA-DOA: 33,004,178–33,009,617, reverse strandHLA-DOAHLA-DPA1: 33,064,569–33,080,781, reverse strandHLA-DPA1HLA-DPB1: 33,073,786–33,091,655, forward strandHLA-DPB1COL11A2: 33,162,681–33,192,802, reverse strandRXRB: 33,193,585–33,200,693, reverse strandRXRBSLC39A7: 33,200,867–33,204,437, forward strandSLC39A7HSD17B8: 33,204,631–33,206,831, forward strandHSD17B8RING1: 33,208,033–33,212,722, forward strandRING1VPS52: 33,250,272–33,272,047, reverse strandVPS52RPS18: 33,271,730–33,276,513, forward strandRPS18B3GALT4: 33,277,123–33,284,832, forward strandB3GALT4WDR46: 33,279,103–33,289,523, reverse strandWDR46PFDN6: 33,288,680–33,298,441, forward strandRGL2: 33,291,180–33,299,534, reverse strandTAPBP: 33,299,694–33,314,284, reverse strandZBTB22: 33,314,406–33,318,021, reverse strandDAXX: 33,318,558–33,323,259, reverse strand: 33,321,386–33,329,286, reverse strandSMIM40: 33,323,628–33,329,279, reverse strandKIFC1: 33,391,429–33,410,441, forward strandKIFC1PHF1: 33,410,360–33,416,453, forward strandPHF1CUTA: 33,416,442–33,418,381, reverse strandCUTASYNGAP1: 33,419,661–33,453,689, forward strandSYNGAP1ZBTB9: 33,453,970–33,457,544, forward strandZBTB9BAK1: 33,568,791–33,580,305, reverse strandBAK1ITPR3: 33,620,331–33,696,575, forward strandITPR3UQCC2: 33,690,635–33,711,748, reverse strandUQCC2Diagram of SLC39A7: 7 exons on the forward strand of chromosome 6Exon 5: 1 known disease-causing siteExon 1: 33,200,867–33,201,656, 790 basesExon 2: 33,201,745–33,201,913, 169 basesExon 3: 33,202,072–33,202,125, 54 basesExon 4: 33,202,263–33,202,427, 165 basesExon 5: 33,202,560–33,202,700, 141 basesExon 6: 33,202,910–33,203,106, 197 basesExon 7: 33,203,541–33,204,437, 897 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 3.6 kb; 1,410 of those bases code for the protein.

How a genome test reads SLC39A7

1

position in SLC39A7 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (100%) falls in a region short reads find hard.

  • MHC (1 site)The major histocompatibility complex (HLA genes), highly polymorphic and poorly represented by a single reference.

A whole genome covers all 3.6 kb of SLC39A7, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC39A7 gene: solute carrier family 39 member 7. Retrieved 16 October 2026, from https://dantelabs.com/genes/slc39a7

Vancouver

Dante Labs. SLC39A7 gene: solute carrier family 39 member 7 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/slc39a7

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