Trait
Barrett esophagus
An abnormal change (metaplasia) in the cells of the inferior portion of the esophagus. The normal squamous epithelium lining of the esophagus is replaced by metaplastic columnar epithelium. Columnar epithelium refers to a cell type that is typically found in more distal parts of the gastrointestinal system.
Summary
- Also called
- Barret syndrome, Barrett oesophagus, Barrett's esophagus, Barrett's oesophagus, Endobrachyesophagus
Reference genomeGRCh38hg38
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Get my Genome Test7 genes linked to Barrett esophagus
Changes in these genes cause rare conditions in which Barrett esophagus is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| RAD21RAD21 cohesin complex component | Always | In 1 condition |
| ERBB2erb-b2 receptor tyrosine kinase 2 | Very often (80–99%) | In 1 condition |
| FHfumarate hydratase | Sometimes (5–29%) | In 1 condition |
| MYH11myosin heavy chain 11 | Sometimes (5–29%) | In 1 condition |
| ASCC1activating signal cointegrator 1 complex subunit 1 | Not recorded | In 1 condition |
| CTHRC1collagen triple helix repeat containing 1 | Not recorded | In 1 condition |
| MSR1macrophage scavenger receptor 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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