Trait

Stapes ankylosis

Stapes ankylosis refers to congenital or acquired fixation of the stapes (the stirrup-shaped small bone or ossicle in the middle ear), which is associated with conductive hearing resulting from impairment of the sound-conduction mechanism (the external auditory canal, tympanic membrane, and/or middle-ear ossicles).

HPO HP:0000381

Also called: Stapes fixation
Body system: Abnormality of the ear

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6 genes linked to Stapes ankylosis

Changes in these genes cause rare conditions in which Stapes ankylosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
NOGnoggin	Very often (80–99%)	In 3 conditions
IL11RAinterleukin 11 receptor subunit alpha	Often (30–79%)	In 1 condition
POU3F4POU class 3 homeobox 4	Often (30–79%)	In 2 conditions
RAD21RAD21 cohesin complex component	Often (30–79%)	In 1 condition
ABCC6ATP binding cassette subfamily C member 6	Sometimes (5–29%)	In 1 condition
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Congenital stapes ankylosis1 gene

Broader traits

Abnormal stapes morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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