Trait

Narrowing of blood vessel below aortic heart valve

Clinical name: Subvalvular aortic stenosis

A fixed form of obstruction to blood flow across the left-ventricular outflow tract related to stenosis (narrowing) below the level of the aortic valve.

HPO HP:0001682

Also called: Subaortic stenosis
Body system: Abnormality of the cardiovascular system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/subvalvular-aortic-stenosis.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

Read the genes linked to Narrowing of blood vessel below aortic heart valve, and the rest of your genome, with one test.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test

21 genes linked to Narrowing of blood vessel below aortic heart valve

Changes in these genes cause rare conditions in which Narrowing of blood vessel below aortic heart valve is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
WDPCPWD repeat containing planar cell polarity effector	Very often (80–99%)	In 2 conditions
CEP57centrosomal protein 57	Often (30–79%)	In 2 conditions
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2	Often (30–79%)	In 1 condition
ZIC3Zic family zinc finger 3	Often (30–79%)	In 1 condition
ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19	Sometimes (5–29%)	In 1 condition
BUB1BUB1 mitotic checkpoint serine/threonine kinase	Sometimes (5–29%)	In 1 condition
BUB1BBUB1 mitotic checkpoint serine/threonine kinase B	Sometimes (5–29%)	In 1 condition
BUB3BUB3 mitotic checkpoint protein	Sometimes (5–29%)	In 1 condition
FOCADfocadhesin	Sometimes (5–29%)	In 1 condition
GNB2G protein subunit beta 2	Sometimes (5–29%)	In 1 condition
HDAC4histone deacetylase 4	Sometimes (5–29%)	In 1 condition
PIGLphosphatidylinositol glycan anchor biosynthesis class L	Sometimes (5–29%)	In 1 condition
PTPN11protein tyrosine phosphatase non-receptor type 11	Sometimes (5–29%)	In 1 condition
SYT2synaptotagmin 2	Sometimes (5–29%)	In 1 condition
TRIP13thyroid hormone receptor interactor 13	Sometimes (5–29%)	In 1 condition
NKX2-5NK2 homeobox 5	Rarely (1–4%)	In 1 condition
CAV3caveolin 3	Not recorded	In 1 condition
FGFR1fibroblast growth factor receptor 1	Not recorded	In 1 condition
IFIH1interferon induced with helicase C domain 1	Not recorded	In 1 condition
MYH6myosin heavy chain 6	Not recorded	In 1 condition
MYH7myosin heavy chain 7	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Muscular subvalvular aortic stenosis1 gene

Broader traits

Abnormal left ventricular outflow tract morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.