Trait
Chronic lung disease
According to the definitions of the American and British Thoracic Societies, including pulmonary functional tests, X-rays, and CT scans for items such as fibrosis, bronchiectasis, bullae, emphysema, nodular or lymphomatous abnormalities.
Summary
- Body system
- Abnormality of the respiratory system
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Get my Genome Test44 genes linked to Chronic lung disease
Changes in these genes cause rare conditions in which Chronic lung disease is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FLVCR1FLVCR choline and heme transporter 1 | Always | In 1 condition |
| LRRC56leucine rich repeat containing 56 | Always | In 1 condition |
| THSD1thrombospondin type 1 domain containing 1 | Always | In 1 condition |
| ITCHitchy E3 ubiquitin protein ligase | Very often (80–99%) | In 2 conditions |
| AFF4ALF transcription elongation factor 4 | Often (30–79%) | In 2 conditions |
| CDONcell adhesion associated, oncogene regulated | Often (30–79%) | In 4 conditions |
| CRIPTOcripto, EGF-CFC family member | Often (30–79%) | In 4 conditions |
| DISP1dispatched RND transporter family member 1 | Often (30–79%) | In 4 conditions |
| DLL1delta like canonical Notch ligand 1 | Often (30–79%) | In 4 conditions |
| FGF8fibroblast growth factor 8 | Often (30–79%) | In 4 conditions |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 2 conditions |
| FOXH1forkhead box H1 | Often (30–79%) | In 4 conditions |
| GAS1growth arrest specific 1 | Often (30–79%) | In 4 conditions |
| GLI2GLI family zinc finger 2 | Often (30–79%) | In 4 conditions |
| LATlinker for activation of T cells | Often (30–79%) | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Often (30–79%) | In 1 condition |
| NODALnodal growth differentiation factor | Often (30–79%) | In 4 conditions |
| PIGYphosphatidylinositol glycan anchor biosynthesis class Y | Often (30–79%) | In 1 condition |
| PLCH1phospholipase C eta 1 | Often (30–79%) | In 1 condition |
| PTCH1patched 1 | Often (30–79%) | In 4 conditions |
| SHHsonic hedgehog signaling molecule | Often (30–79%) | In 4 conditions |
| SIX3SIX homeobox 3 | Often (30–79%) | In 4 conditions |
| SMC1Astructural maintenance of chromosomes 1A | Often (30–79%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 2 conditions |
| STAT5Bsignal transducer and activator of transcription 5B | Often (30–79%) | In 1 condition |
| STILSTIL centriolar assembly protein | Often (30–79%) | In 4 conditions |
| TGIF1TGFB induced factor homeobox 1 | Often (30–79%) | In 4 conditions |
| ZIC2Zic family zinc finger 2 | Often (30–79%) | In 4 conditions |
| CSPP1centrosome and spindle pole associated protein 1 | Sometimes (5–29%) | In 1 condition |
| CTCFCCCTC-binding factor | Sometimes (5–29%) | In 1 condition |
| FOXE1forkhead box E1 | Sometimes (5–29%) | In 1 condition |
| HABP2hyaluronan binding protein 2 | Sometimes (5–29%) | In 1 condition |
| KIAA0586KIAA0586 | Sometimes (5–29%) | In 1 condition |
| MINPP1multiple inositol-polyphosphate phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| PRIM1DNA primase subunit 1 | Sometimes (5–29%) | In 1 condition |
| RIPK1receptor interacting serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| SFTPBsurfactant protein B | Sometimes (5–29%) | In 1 condition |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| BLMBLM RecQ like helicase | Not recorded | In 1 condition |
| CFTRCF transmembrane conductance regulator | Not recorded | In 1 condition |
Show 4 more genes
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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