Trait
Panhypopituitarism
A pituitary functional deficit affecting all the anterior pituitary hormones (growth hormone, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotropic hormone, and prolactin).
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Panhypopituitarism, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test31 genes linked to Panhypopituitarism
Changes in these genes cause rare conditions in which Panhypopituitarism is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| HESX1HESX homeobox 1 | Often (30–79%) | In 1 condition |
| LHX3LIM homeobox 3 | Often (30–79%) | In 1 condition |
| LHX4LIM homeobox 4 | Often (30–79%) | In 1 condition |
| MADDMAP kinase activating death domain | Often (30–79%) | In 1 condition |
| POU1F1POU class 1 homeobox 1 | Often (30–79%) | In 1 condition |
| PROP1PROP paired-like homeobox 1 | Often (30–79%) | In 2 conditions |
| RNF113Aring finger protein 113A | Often (30–79%) | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Sometimes (5–29%) | In 5 conditions |
| CRIPTOcripto, EGF-CFC family member | Sometimes (5–29%) | In 5 conditions |
| DISP1dispatched RND transporter family member 1 | Sometimes (5–29%) | In 5 conditions |
| DLL1delta like canonical Notch ligand 1 | Sometimes (5–29%) | In 5 conditions |
| FGF8fibroblast growth factor 8 | Sometimes (5–29%) | In 5 conditions |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 3 conditions |
| FOXH1forkhead box H1 | Sometimes (5–29%) | In 5 conditions |
| GAS1growth arrest specific 1 | Sometimes (5–29%) | In 5 conditions |
| GLI2GLI family zinc finger 2 | Sometimes (5–29%) | In 6 conditions |
| GLI3GLI family zinc finger 3 | Sometimes (5–29%) | In 2 conditions |
| GRM7glutamate metabotropic receptor 7 | Sometimes (5–29%) | In 1 condition |
| NODALnodal growth differentiation factor | Sometimes (5–29%) | In 5 conditions |
| PLCH1phospholipase C eta 1 | Sometimes (5–29%) | In 1 condition |
| PTCH1patched 1 | Sometimes (5–29%) | In 6 conditions |
| SHHsonic hedgehog signaling molecule | Sometimes (5–29%) | In 5 conditions |
| SIX3SIX homeobox 3 | Sometimes (5–29%) | In 5 conditions |
| SMC1Astructural maintenance of chromosomes 1A | Sometimes (5–29%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Sometimes (5–29%) | In 2 conditions |
| STILSTIL centriolar assembly protein | Sometimes (5–29%) | In 4 conditions |
| SUFUSUFU negative regulator of hedgehog signaling | Sometimes (5–29%) | In 1 condition |
| TGIF1TGFB induced factor homeobox 1 | Sometimes (5–29%) | In 5 conditions |
| ZIC2Zic family zinc finger 2 | Sometimes (5–29%) | In 5 conditions |
| KATNIPkatanin interacting protein | Not recorded | In 1 condition |
| SOX3SRY-box transcription factor 3 | Not recorded | In 2 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks