Trait
Hyposmia
A decreased sensitivity to odorants (that is, a decreased ability to perceive odors).
Summary
- Also called
- Decreased smell sensation, Sense of smell impaired
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test55 genes linked to Hyposmia
Changes in these genes cause rare conditions in which Hyposmia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP7BATPase copper transporting beta | Always | In 1 condition |
| RAB3ARAB3A, member RAS oncogene family | Always | In 1 condition |
| SCP2sterol carrier protein 2 | Always | In 1 condition |
| ANOS1anosmin 1 | Very often (80–99%) | In 2 conditions |
| CCDC141coiled-coil domain containing 141 | Very often (80–99%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Very often (80–99%) | In 1 condition |
| DCCDCC netrin 1 receptor | Very often (80–99%) | In 1 condition |
| DUSP6dual specificity phosphatase 6 | Very often (80–99%) | In 1 condition |
| EMX2empty spiracles homeobox 2 | Very often (80–99%) | In 1 condition |
| FEZF1FEZ family zinc finger 1 | Very often (80–99%) | In 1 condition |
| FGF17fibroblast growth factor 17 | Very often (80–99%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Very often (80–99%) | In 2 conditions |
| FGFR1fibroblast growth factor receptor 1 | Very often (80–99%) | In 2 conditions |
| FLRT3fibronectin leucine rich transmembrane protein 3 | Very often (80–99%) | In 2 conditions |
| HESX1HESX homeobox 1 | Very often (80–99%) | In 1 condition |
| HS6ST1heparan sulfate 6-O-sulfotransferase 1 | Very often (80–99%) | In 1 condition |
| IL17RDinterleukin 17 receptor D | Very often (80–99%) | In 1 condition |
| NDNFneuron derived neurotrophic factor | Very often (80–99%) | In 1 condition |
| PROK2prokineticin 2 | Very often (80–99%) | In 2 conditions |
| PROKR2prokineticin receptor 2 | Very often (80–99%) | In 2 conditions |
| RAB32RAB32, member RAS oncogene family | Very often (80–99%) | In 1 condition |
| SEMA3Asemaphorin 3A | Very often (80–99%) | In 2 conditions |
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Very often (80–99%) | In 1 condition |
| SOX10SRY-box transcription factor 10 | Very often (80–99%) | In 1 condition |
| SPRY4sprouty RTK signaling antagonist 4 | Very often (80–99%) | In 2 conditions |
| TACR3tachykinin receptor 3 | Very often (80–99%) | In 1 condition |
| WDR11WD repeat domain 11 | Very often (80–99%) | In 1 condition |
| ADCY3adenylate cyclase 3 | Often (30–79%) | In 1 condition |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Often (30–79%) | In 1 condition |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Often (30–79%) | In 1 condition |
| EPG5ectopic P-granules 5 autophagy tethering factor | Often (30–79%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Often (30–79%) | In 1 condition |
| GIGYF2GRB10 interacting GYF protein 2 | Often (30–79%) | In 1 condition |
| LRRK2leucine rich repeat kinase 2 | Often (30–79%) | In 3 conditions |
| LZTFL1leucine zipper transcription factor like 1 | Often (30–79%) | In 1 condition |
| SNCAsynuclein alpha | Often (30–79%) | In 2 conditions |
| VPS35VPS35 retromer complex component | Often (30–79%) | In 1 condition |
| DDX6DEAD-box helicase 6 | Sometimes (5–29%) | In 1 condition |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Sometimes (5–29%) | In 1 condition |
| HTRA2HtrA serine peptidase 2 | Sometimes (5–29%) | In 1 condition |
Show 15 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PARK7Parkinsonism associated deglycase | Sometimes (5–29%) | In 1 condition |
| PINK1PTEN induced kinase 1 | Sometimes (5–29%) | In 1 condition |
| PODXLpodocalyxin like | Sometimes (5–29%) | In 1 condition |
| PRKNparkin RBR E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| SYNJ1synaptojanin 1 | Sometimes (5–29%) | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Sometimes (5–29%) | In 1 condition |
| VPS13Cvacuolar protein sorting 13 homolog C | Sometimes (5–29%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Not recorded | In 1 condition |
| CEP290centrosomal protein 290 | Not recorded | In 1 condition |
| IFT27intraflagellar transport 27 | Not recorded | In 1 condition |
| NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor | Not recorded | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Not recorded | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Not recorded | In 1 condition |
| SLC39A14solute carrier family 39 member 14 | Not recorded | In 1 condition |
| TSHZ1teashirt zinc finger homeobox 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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