Trait

Oromotor apraxia

Oral-motor apraxia is the inability to volitionally sequence oral movements of the speech structure for nonspeech tasks in the absence of neuromuscular deficits such as paralysis or muscle weakness. Oral-motor apraxia is diagnosed when, despite intact sensory motor function an individual is unable to use these effector systems under voluntary control.

HPO HP:0007301

Also called: Oral-motor apraxia
Body system: Abnormality of the nervous system

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29 genes linked to Oromotor apraxia

Changes in these genes cause rare conditions in which Oromotor apraxia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
NOS3nitric oxide synthase 3	Always	In 1 condition
DDOSTdolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Very often (80–99%)	In 1 condition
CDONcell adhesion associated, oncogene regulated	Often (30–79%)	In 4 conditions
CRIPTOcripto, EGF-CFC family member	Often (30–79%)	In 4 conditions
DISP1dispatched RND transporter family member 1	Often (30–79%)	In 4 conditions
DLL1delta like canonical Notch ligand 1	Often (30–79%)	In 4 conditions
FGF8fibroblast growth factor 8	Often (30–79%)	In 4 conditions
FGFR1fibroblast growth factor receptor 1	Often (30–79%)	In 2 conditions
FOXH1forkhead box H1	Often (30–79%)	In 4 conditions
FOXP1forkhead box P1	Often (30–79%)	In 1 condition
GAS1growth arrest specific 1	Often (30–79%)	In 4 conditions
GLI2GLI family zinc finger 2	Often (30–79%)	In 4 conditions
NODALnodal growth differentiation factor	Often (30–79%)	In 4 conditions
PLCH1phospholipase C eta 1	Often (30–79%)	In 1 condition
PTCH1patched 1	Often (30–79%)	In 4 conditions
SHHsonic hedgehog signaling molecule	Often (30–79%)	In 4 conditions
SIX3SIX homeobox 3	Often (30–79%)	In 4 conditions
SMC1Astructural maintenance of chromosomes 1A	Often (30–79%)	In 1 condition
STAG2STAG2 cohesin complex component	Often (30–79%)	In 2 conditions
STILSTIL centriolar assembly protein	Often (30–79%)	In 4 conditions
TGIF1TGFB induced factor homeobox 1	Often (30–79%)	In 4 conditions
VPS11VPS11 core subunit of CORVET and HOPS complexes	Often (30–79%)	In 1 condition
ZIC2Zic family zinc finger 2	Often (30–79%)	In 4 conditions
ADGRG1adhesion G protein-coupled receptor G1	Sometimes (5–29%)	In 1 condition
CLTCclathrin heavy chain	Sometimes (5–29%)	In 1 condition
PI4KAphosphatidylinositol 4-kinase alpha	Sometimes (5–29%)	In 1 condition
SRPX2sushi repeat containing protein X-linked 2	Sometimes (5–29%)	In 1 condition
TUBB2Btubulin beta 2B class IIb	Sometimes (5–29%)	In 1 condition
FOXP2forkhead box P2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Apraxia

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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