Trait
Cyclops eye
Clinical name: Cyclopia
Cyclopia is a congenital abnormality in which there is only one eye. That eye is centrally placed in the area normally occupied by the root of the nose.
Summary
- Also called
- Single central eye
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Cyclops eye, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test23 genes linked to Cyclops eye
Changes in these genes cause rare conditions in which Cyclops eye is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| OTX2orthodenticle homeobox 2 | Very often (80–99%) | In 1 condition |
| PRRX1paired related homeobox 1 | Very often (80–99%) | In 1 condition |
| PLCH1phospholipase C eta 1 | Often (30–79%) | In 2 conditions |
| CDONcell adhesion associated, oncogene regulated | Sometimes (5–29%) | In 5 conditions |
| CRIPTOcripto, EGF-CFC family member | Sometimes (5–29%) | In 5 conditions |
| DISP1dispatched RND transporter family member 1 | Sometimes (5–29%) | In 5 conditions |
| DLL1delta like canonical Notch ligand 1 | Sometimes (5–29%) | In 5 conditions |
| FGF8fibroblast growth factor 8 | Sometimes (5–29%) | In 5 conditions |
| FGFR1fibroblast growth factor receptor 1 | Sometimes (5–29%) | In 3 conditions |
| FOXH1forkhead box H1 | Sometimes (5–29%) | In 5 conditions |
| GAS1growth arrest specific 1 | Sometimes (5–29%) | In 5 conditions |
| GLI2GLI family zinc finger 2 | Sometimes (5–29%) | In 5 conditions |
| NODALnodal growth differentiation factor | Sometimes (5–29%) | In 5 conditions |
| PTCH1patched 1 | Sometimes (5–29%) | In 5 conditions |
| SHHsonic hedgehog signaling molecule | Sometimes (5–29%) | In 7 conditions |
| SIX3SIX homeobox 3 | Sometimes (5–29%) | In 6 conditions |
| SMC1Astructural maintenance of chromosomes 1A | Sometimes (5–29%) | In 1 condition |
| STAG2STAG2 cohesin complex component | Sometimes (5–29%) | In 3 conditions |
| STILSTIL centriolar assembly protein | Sometimes (5–29%) | In 4 conditions |
| SUFUSUFU negative regulator of hedgehog signaling | Sometimes (5–29%) | In 1 condition |
| TBC1D32TBC1 domain family member 32 | Sometimes (5–29%) | In 1 condition |
| TGIF1TGFB induced factor homeobox 1 | Sometimes (5–29%) | In 5 conditions |
| ZIC2Zic family zinc finger 2 | Sometimes (5–29%) | In 5 conditions |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks