Trait

Premature plaque build-up in arteries

Clinical name: Precocious atherosclerosis

HPO HP:0004416

Also called: Premature atherosclerosis
Body system: Abnormality of the cardiovascular system

Read the genes linked to Premature plaque build-up in arteries, and the rest of your genome, with one test.

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10 genes linked to Premature plaque build-up in arteries

Changes in these genes cause rare conditions in which Premature plaque build-up in arteries is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ABCG5ATP binding cassette subfamily G member 5	Very often (80–99%)	In 1 condition
ABCG8ATP binding cassette subfamily G member 8	Very often (80–99%)	In 1 condition
APOBapolipoprotein B	Very often (80–99%)	In 1 condition
LDLRlow density lipoprotein receptor	Very often (80–99%)	In 1 condition
LDLRAP1low density lipoprotein receptor adaptor protein 1	Very often (80–99%)	In 1 condition
PCSK9proprotein convertase subtilisin/kexin type 9	Very often (80–99%)	In 1 condition
LMNAlamin A/C	Often (30–79%)	In 2 conditions
CYP27A1cytochrome P450 family 27 subfamily A member 1	Sometimes (5–29%)	In 1 condition
APOA5apolipoprotein A5	Not recorded	In 1 condition
APOEapolipoprotein E	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Narrowing and hardening of arteries

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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