Skip to content
Use your HSA or FSA funds

Gene

GPIHBP1

glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Summary

Cytogenetic location
8q24.3
Coordinates
Chromosome 8: 143,213,218–143,217,170 (GRCh38)
Exons
4 exons across 4 kb
Protein
184 amino acids
Also known as
LOC338328, GPI-HBP1
MANE Select transcript
ENST00000622500.2NM_178172.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

How GPIHBP1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 8, with a bracket where GPIHBP1 sits. GPIHBP1 and 32 genes near it on chromosome 8, from 142,715,194 to 143,715,193.Chromosome 88q24.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3142.8 Mb143 Mb143.2 Mb143.4 Mb143.6 MbTHEM6: 142,727,176–142,736,938, forward strandSLURP1: 142,740,941–142,742,414, reverse strandLYPD2: 142,750,150–142,753,006, reverse strandLYNX1-SLURP2: 142,764,334–142,778,224, reverse strandLYNX1-SLURP2SLURP2: 142,764,334–142,769,828, reverse strandSLURP2LYNX1: 142,771,197–142,777,889, reverse strandLYNX1LY6D: 142,784,881–142,786,546, reverse strandLY6DGML: 142,834,171–142,916,506, forward strandGMLCYP11B1: 142,871,305–142,880,000, reverse strandCYP11B1CYP11B2: 142,910,424–142,917,943, reverse strandCYP11B2LY6E: 143,012,722–143,023,835, forward strandLY6ELY6S: 143,040,839–143,048,357, reverse strandLY6SLY6L: 143,080,299–143,083,486, forward strandLY6LLY6H: 143,157,914–143,160,711, reverse strandLY6HGPIHBP1: 143,213,218–143,217,170, forward strandGPIHBP1ZFP41: 143,245,996–143,262,705, forward strandZFP41: 143,247,110–143,276,403, forward strandGLI4: 143,263,193–143,276,937, forward strandGLI4ZNF696: 143,289,676–143,299,952, forward strandZNF696TOP1MT: 143,301,453–143,359,979, reverse strandTOP1MTRHPN1: 143,368,810–143,384,221, forward strandRHPN1MAFA: 143,419,182–143,430,732, reverse strandMAFAZC3H3: 143,437,655–143,541,578, reverse strandZC3H3GSDMD: 143,553,207–143,563,062, forward strandGSDMDMROH6: 143,566,188–143,573,110, reverse strandMROH6NAPRT: 143,574,782–143,578,649, reverse strandNAPRTEEF1D: 143,579,697–143,599,541, reverse strandEEF1DTIGD5: 143,597,831–143,603,224, forward strandPYCR3: 143,603,210–143,609,773, reverse strandGFUS: 143,612,617–143,618,048, reverse strandZNF623: 143,635,518–143,656,418, forward strandZNF623ZNF707: 143,684,452–143,713,898, forward strandZNF707CCDC166: 143,706,694–143,708,109, reverse strandCCDC166Diagram of GPIHBP1: 4 exons on the forward strand of chromosome 8Exon 3: 2 known disease-causing sitesExon 4: 9 known disease-causing sitesExon 1: 143,213,218–143,213,319, 102 basesExon 2: 143,213,822–143,213,950, 129 basesExon 3: 143,215,013–143,215,126, 114 basesExon 4: 143,215,259–143,217,170, 1,912 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 4 kb; 555 of those bases code for the protein.

How a genome test reads GPIHBP1

13

positions in GPIHBP1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4 kb of GPIHBP1, introns included, not only the 2.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPIHBP1 gene: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/gpihbp1

Vancouver

Dante Labs. GPIHBP1 gene: glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gpihbp1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test