Trait

Accelerated plaque build-up in arteries

Clinical name: Accelerated atherosclerosis

Atherosclerosis which occurs in a person with certain risk factors (e.g., SLE, diabetes, smoking, hypertension, hypercholesterolaemia, family history of early heart disease) at an earlier age than would occur in another person without those risk factors.

HPO HP:0004943

Body system: Abnormality of the cardiovascular system

This page as data

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library(jsonlite)

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page <- fromJSON(url)
page$trait$name

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8 genes linked to Accelerated plaque build-up in arteries

Changes in these genes cause rare conditions in which Accelerated plaque build-up in arteries is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ABCA1ATP binding cassette subfamily A member 1	Often (30–79%)	In 1 condition
CYP7A1cytochrome P450 family 7 subfamily A member 1	Often (30–79%)	In 1 condition
LMNAlamin A/C	Often (30–79%)	In 1 condition
APOEapolipoprotein E	Sometimes (5–29%)	In 1 condition
ABCC6ATP binding cassette subfamily C member 6	Not recorded	In 1 condition
CELA2Achymotrypsin like elastase 2A	Not recorded	In 1 condition
XYLT1xylosyltransferase 1	Not recorded	In 1 condition
XYLT2xylosyltransferase 2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Narrowing and hardening of arteries

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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