Trait
Corneal arcus
A hazy, grayish-white ring about 2 mm in width located close to but separated from the limbus (the corneoscleral junction). Corneal arcus generally occurs bilaterally, and is related to lipid deposition in the cornea. Corneal arcus can occur in elderly persons as a part of the aging process but may be associated with hypercholesterolemia in people under the age of 50 years.
Summary
- Also called
- Anterior embryotoxon, Arcus lipoidis, Arcus senilis, Corneal annulus, Gerontoxon
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test17 genes linked to Corneal arcus
Changes in these genes cause rare conditions in which Corneal arcus is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCG8ATP binding cassette subfamily G member 8 | Always | In 1 condition |
| LCATlecithin-cholesterol acyltransferase | Always | In 1 condition |
| APOEapolipoprotein E | Often (30–79%) | In 1 condition |
| CHRDL1chordin like 1 | Often (30–79%) | In 1 condition |
| LIPClipase C, hepatic type | Often (30–79%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Often (30–79%) | In 2 conditions |
| APOA1apolipoprotein A1 | Sometimes (5–29%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Not recorded | In 1 condition |
| APOA2apolipoprotein A2 | Not recorded | In 1 condition |
| APOBapolipoprotein B | Not recorded | In 1 condition |
| EPHX2epoxide hydrolase 2 | Not recorded | In 1 condition |
| GHRgrowth hormone receptor | Not recorded | In 1 condition |
| KERAkeratocan | Not recorded | In 1 condition |
| LDLRlow density lipoprotein receptor | Not recorded | In 1 condition |
| PCSK9proprotein convertase subtilisin/kexin type 9 | Not recorded | In 1 condition |
| PPP1R17protein phosphatase 1 regulatory subunit 17 | Not recorded | In 1 condition |
| UBIAD1UbiA prenyltransferase domain containing 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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