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Gene

LIPC

lipase C, hepatic type

Summary

Cytogenetic location
15q21.3
Coordinates
Chromosome 15: 58,431,991–58,569,844 (GRCh38)
Exons
9 exons across 137.9 kb
Protein
499 amino acids
Also known as
HL, HTGL
MANE Select transcript
ENST00000299022.10NM_000236.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

How LIPC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where LIPC sits. LIPC and 6 genes near it on chromosome 15, from 58,000,918 to 59,000,917.Chromosome 1515q21.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.358.2 Mb58.4 Mb58.6 Mb58.8 Mb59 MbALDH1A2: 57,953,424–58,497,866, reverse strandALDH1A2AQP9: 58,138,169–58,185,915, forward strandAQP9LIPC: 58,431,991–58,569,844, forward strandLIPCADAM10: 58,588,809–58,749,871, reverse strandADAM10MINDY2: 58,771,117–58,861,900, forward strandMINDY2RNF111: 58,865,175–59,097,508, forward strandRNF111SLTM: 58,879,046–58,934,012, reverse strandSLTMDiagram of LIPC: 9 exons on the forward strand of chromosome 15Exon 2: 1 known disease-causing siteExon 1: 58,431,991–58,432,120, 130 basesExon 2: 58,538,333–58,538,517, 185 basesExon 3: 58,541,785–58,541,967, 183 basesExon 4: 58,542,534–58,542,651, 118 basesExon 5: 58,545,742–58,545,975, 234 basesExon 6: 58,548,330–58,548,572, 243 basesExon 7: 58,560,864–58,560,981, 118 basesExon 8: 58,563,505–58,563,723, 219 basesExon 9: 58,568,716–58,569,844, 1,129 bases1246895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 137.9 kb; 1,500 of those bases code for the protein.

Sequencing LIPC

1

position in LIPC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 137.9 kb of LIPC, introns included, not only the 2.6 kb of exons.

Genes linked to the same conditions

Traits linked to LIPC

The Human Phenotype Ontology lists these as features of the rare conditions LIPC can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). LIPC gene: lipase C, hepatic type. Retrieved 17 October 2026, from https://dantelabs.com/genes/lipc

Vancouver

Dante Labs. LIPC gene: lipase C, hepatic type [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lipc

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