Trait
Foam cells
The presence of foam cells, a type of macrophage that localizes to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.
Summary
- Also called
- Foamy histiocytes, Foamy macrophages, Lipid-laden histiocytes, Presence of foam cells
- Body system
- Abnormality of the cardiovascular system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test11 genes linked to Foam cells
Changes in these genes cause rare conditions in which Foam cells is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APOEapolipoprotein E | Always | In 1 condition |
| PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Always | In 1 condition |
| RBSNrabenosyn, RAB effector | Always | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| CSF2RAcolony stimulating factor 2 receptor subunit alpha | Sometimes (5–29%) | In 1 condition |
| CSF2RBcolony stimulating factor 2 receptor subunit beta | Sometimes (5–29%) | In 1 condition |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Sometimes (5–29%) | In 1 condition |
| GLB1galactosidase beta 1 | Not recorded | In 1 condition |
| LCATlecithin-cholesterol acyltransferase | Not recorded | In 1 condition |
| NPC1NPC intracellular cholesterol transporter 1 | Not recorded | In 1 condition |
| NPC2NPC intracellular cholesterol transporter 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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