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Gene

CEACAM16

CEA cell adhesion molecule 16, tectorial membrane component

Summary

Cytogenetic location
19q13.31-q13.32
Coordinates
Chromosome 19: 44,699,151–44,710,718 (GRCh38)
Exons
7 exons across 11.6 kb
Protein
425 amino acids
Inheritance
Autosomal dominant
Also known as
DFNA4B
MANE Select transcript
ENST00000587331.7NM_001039213.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Hearing Loss and Deafness

    • Autosomal Dominant Nonsyndromic Hearing LossAutosomal dominant

      Autosomal dominant form of nonsyndromic deafness.

      • 1 GenCC submitter rates it definitive or strong
    • Nonsyndromic Genetic Hearing Loss

      One of 97 genes linked to it

      Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

      • ClinGen rates the link strong
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How CEACAM16 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where CEACAM16 sits. CEACAM16 and 32 genes near it on chromosome 19, from 44,204,935 to 45,204,934.Chromosome 1919q13.31-q13.32p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4344.4 Mb44.6 Mb44.8 Mb45 Mb45.2 MbZNF227: 44,207,475–44,238,179, forward strandZNF227ZNF235: 44,228,729–44,305,046, reverse strandZNF235ZNF233: 44,259,863–44,277,043, forward strandZNF233ZNF112: 44,307,664–44,367,217, reverse strandZNF112: 44,329,695–44,401,608, reverse strandZNF285: 44,382,298–44,401,624, reverse strandZNF285ZNF229: 44,417,519–44,448,578, reverse strandZNF229ZNF180: 44,470,957–44,500,547, reverse strandZNF180CEACAM20: 44,501,677–44,529,788, reverse strandCEACAM20IGSF23: 44,613,563–44,636,787, forward strandIGSF23PVR: 44,643,798–44,666,162, forward strandPVRCEACAM19: 44,662,278–44,684,370, forward strandCEACAM19CEACAM16: 44,699,151–44,710,718, forward strandCEACAM16BCL3: 44,747,705–44,760,044, forward strandBCL3CBLC: 44,777,845–44,802,301, forward strandCBLCBCAM: 44,809,040–44,821,421, forward strandBCAMNECTIN2: 44,846,175–44,890,134, forward strandNECTIN2TOMM40: 44,890,569–44,903,695, forward strandTOMM40APOE: 44,903,787–44,909,396, forward strandAPOEAPOC1: 44,913,133–44,920,054, forward strandAPOC1APOC2: 44,936,126–44,949,585, forward strandAPOC2APOC4: 44,942,234–44,945,496, forward strandAPOC4-APOC2: 44,942,238–44,949,565, forward strandCLPTM1: 44,954,585–44,993,342, forward strandCLPTM1RELB: 45,001,431–45,038,194, forward strandRELBCLASRP: 45,039,042–45,070,956, forward strandCLASRPZNF296: 45,071,500–45,076,485, reverse strandZNF296GEMIN7: 45,075,575–45,091,518, forward strandGEMIN7MARK4: 45,079,288–45,305,284, forward strandPPP1R37: 45,091,396–45,148,077, forward strandPPP1R37NKPD1: 45,149,744–45,160,982, reverse strandNKPD1BLOC1S3: 45,152,811–45,216,933, forward strandBLOC1S3TRAPPC6A: 45,162,928–45,178,268, reverse strandTRAPPC6ADiagram of CEACAM16: 7 exons on the forward strand of chromosome 19Exon 2: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 4 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 1: 44,699,151–44,699,260, 110 basesExon 2: 44,701,361–44,701,493, 133 basesExon 3: 44,703,349–44,703,693, 345 basesExon 4: 44,704,018–44,704,296, 279 basesExon 5: 44,705,590–44,705,868, 279 basesExon 6: 44,707,861–44,708,187, 327 basesExon 7: 44,710,496–44,710,718, 223 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 11.6 kb; 1,278 of those bases code for the protein.

How a genome test reads CEACAM16

11

positions in CEACAM16 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 11.6 kb of CEACAM16, introns included, not only the 1.7 kb of exons.

Genes linked to the same conditions

Traits linked to CEACAM16

The Human Phenotype Ontology lists these as features of the rare conditions CEACAM16 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CEACAM16 gene: CEA cell adhesion molecule 16, tectorial membrane component. Retrieved 17 October 2026, from https://dantelabs.com/genes/ceacam16

Vancouver

Dante Labs. CEACAM16 gene: CEA cell adhesion molecule 16, tectorial membrane component [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ceacam16

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