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Gene

APOA5

apolipoprotein A5

Summary

Cytogenetic location
11q23.3
Coordinates
Chromosome 11: 116,789,367–116,791,879 (GRCh38)
Exons
3 exons across 2.5 kb
Protein
366 amino acids
Also known as
RAP3, APOA-V
MANE Select transcript
ENST00000227665.9NM_001371904.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hyperlipidemia

      • 4 GenCC submitters rate it definitive or strong

  • Hypertriglyceridemia

    • A laboratory test result indicating elevated triglyceride concentration in the blood.

      • 1 GenCC submitter rates it definitive or strong

How APOA5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 11, with a bracket where APOA5 sits. APOA5 and 12 genes near it on chromosome 11, from 116,290,623 to 117,290,622.Chromosome 1111q23.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25116.4 Mb116.6 Mb116.8 Mb117 Mb117.2 MbBUD13: 116,748,170–116,773,039, reverse strandBUD13ZPR1: 116,773,799–116,788,477, reverse strandZPR1APOA5: 116,789,367–116,791,879, reverse strandAPOA5APOA4: 116,820,700–116,823,427, reverse strandAPOA4APOC3: 116,827,019–116,835,254, forward strandAPOC3APOA1: 116,834,677–116,842,065, reverse strandAPOA1SIK3: 116,843,402–117,098,463, reverse strandSIK3PAFAH1B2: 117,144,278–117,176,894, forward strandPAFAH1B2SIDT2: 117,178,730–117,197,452, forward strandSIDT2TAGLN: 117,197,509–117,207,464, forward strandTAGLNPCSK7: 117,202,588–117,232,628, reverse strandPCSK7RNF214: 117,232,154–117,287,429, forward strandRNF214BACE1: 117,285,232–117,316,291, reverse strandBACE1Diagram of APOA5: 3 exons on the reverse strand of chromosome 11Exon 3: 8 known disease-causing sitesExon 2: 1 known disease-causing siteExon 3: 116,789,367–116,791,067, 1,701 basesExon 2: 116,791,586–116,791,697, 112 basesExon 1: 116,791,812–116,791,879, 68 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 2.5 kb; 1,101 of those bases code for the protein.

How a genome test reads APOA5

9

positions in APOA5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 2.5 kb of APOA5, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). APOA5 gene: apolipoprotein A5. Retrieved 17 October 2026, from https://dantelabs.com/genes/apoa5

Vancouver

Dante Labs. APOA5 gene: apolipoprotein A5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/apoa5

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