Skip to content
Use your HSA or FSA funds

Gene

MRM2

mitochondrial rRNA methyltransferase 2

Summary

Cytogenetic location
7p22.3
Coordinates
Chromosome 7: 2,234,195–2,242,205 (GRCh38)
Exons
3 exons across 8 kb
Protein
246 amino acids
Also known as
FJH1, RRMJ2
Previous symbols
FTSJ2
MANE Select transcript
ENST00000242257.14NM_013393.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Mitochondrial Disease

    • Mitochondrial DNA Depletion Syndrome

      Caused by variants in nuclear genes such as POLG, TWNK, TK2, DGUOK, MPV17, RRM2B and SUCLA2, which reduce the amount of mitochondrial DNA and can cause muscle, liver or brain disease.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing is directly actionable: valproate must be avoided in POLG disease because of the risk of fatal liver failure, and TK2 deficiency has a nucleoside therapy.

How MRM2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 7, with a bracket where MRM2 sits. MRM2 and 14 genes near it on chromosome 7, from 1,738,200 to 2,738,199.Chromosome 77p22.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.31.8 Mb2 Mb2.2 Mb2.4 Mb2.6 MbELFN1: 1,665,745–1,747,946, forward strandELFN1MAD1L1: 1,815,787–2,233,243, reverse strandMAD1L1: 1,815,804–2,242,215, reverse strandMRM2: 2,234,195–2,242,205, reverse strandMRM2NUDT1: 2,242,203–2,251,824, forward strandNUDT1SNX8: 2,251,770–2,354,318, reverse strandSNX8EIF3B: 2,354,080–2,380,747, forward strandEIF3BCHST12: 2,403,442–2,448,484, forward strandCHST12GRIFIN: 2,474,728–2,476,894, reverse strandGRIFINLFNG: 2,512,529–2,529,177, forward strandLFNGBRAT1: 2,537,784–2,555,782, reverse strandBRAT1IQCE: 2,558,903–2,614,733, forward strandIQCETTYH3: 2,631,898–2,664,816, forward strandTTYH3AMZ1: 2,679,276–2,775,500, forward strandAMZ1GNA12: 2,721,820–2,870,786, reverse strandGNA12Diagram of MRM2: 3 exons on the reverse strand of chromosome 7Exon 3: 2,234,195–2,235,564, 1,370 basesExon 2: 2,239,418–2,239,707, 290 basesExon 1: 2,242,162–2,242,205, 44 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 8 kb; 741 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MRM2 gene: mitochondrial rRNA methyltransferase 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/mrm2

Vancouver

Dante Labs. MRM2 gene: mitochondrial rRNA methyltransferase 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mrm2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test