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Gene

H4C3

H4 clustered histone 3

Summary

Cytogenetic location
6p22.2
Coordinates
Chromosome 6: 26,103,933–26,104,337 (GRCh38)
Exons
1 exon across 0.4 kb
Protein
103 amino acids
Also known as
H4/g, dJ221C16.1
Previous symbols
H4FG, HIST1H4C
MANE Select transcript
ENST00000377803.4NM_003542.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads H4C3 yet. The test sequences your whole genome, so your data includes it all the same.

How H4C3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 6, with a bracket where H4C3 sits. H4C3 and 51 genes near it on chromosome 6, from 25,604,135 to 26,604,134.Chromosome 66p22.2p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2725.8 Mb26 Mb26.2 Mb26.4 Mb26.6 MbCARMIL1: 25,279,062–25,620,537, forward strandCARMIL1SCGN: 25,652,201–25,701,792, forward strandSCGN: 25,652,210–25,738,044, forward strandH2AC1: 25,723,397–25,726,562, reverse strandH2AC1H2BC1: 25,726,777–25,727,345, forward strandH2BC1SLC17A4: 25,753,300–25,783,316, forward strandSLC17A4SLC17A1: 25,781,532–25,832,067, reverse strandSLC17A1SLC17A3: 25,833,066–25,882,478, reverse strandSLC17A3SLC17A2: 25,906,892–25,930,815, reverse strandSLC17A2TRIM38: 25,962,693–25,991,231, forward strandTRIM38H1-1: 26,017,032–26,017,787, reverse strandH3C1: 26,020,451–26,021,487, forward strandH4C1: 26,021,649–26,022,847, forward strandH4C2: 26,025,802–26,027,283, reverse strandH3C2: 26,028,850–26,032,102, reverse strandH2AC4: 26,033,092–26,033,618, reverse strandH2AC4H2BC3: 26,042,771–26,043,713, reverse strandH2BC3H3C3: 26,045,384–26,045,869, forward strandH3C3H1-2: 26,054,760–26,056,470, reverse strandH1-2H2BC4: 26,067,392–26,124,016, reverse strandH2BC4HFE: 26,087,226–26,098,343, forward strandHFEH4C3: 26,103,933–26,104,337, forward strandH4C3H1-6: 26,107,412–26,108,135, reverse strandH1-6H2AC6: 26,124,145–26,139,116, forward strandH1-4: 26,156,329–26,157,115, forward strandH1-4H2BC5: 26,158,122–26,171,349, forward strandH2BC5H2BC6: 26,172,059–26,184,655, forward strandH2BC6H4C4: 26,188,710–26,189,112, reverse strandH4C4H3C4: 26,195,164–26,197,286, reverse strand: 26,195,595–26,199,293, reverse strandH2AC7: 26,198,784–26,199,293, reverse strandH2BC7: 26,199,516–26,199,988, forward strandH4C5: 26,204,610–26,205,021, forward strandH2BC8: 26,214,570–26,217,252, reverse strandH2AC8: 26,216,921–26,218,515, forward strandH3C6: 26,224,179–26,227,476, forward strandH1-3: 26,234,212–26,234,987, reverse strandH1-3H4C6: 26,240,393–26,240,793, forward strandH4C6H4C7: 26,246,611–26,246,996, reverse strandH4C7H3C7: 26,250,142–26,250,635, reverse strandH2BC9: 26,251,614–26,252,075, forward strandH3C8: 26,270,918–26,271,413, reverse strandH2BC10: 26,272,931–26,273,412, forward strandH4C8: 26,277,609–26,285,638, reverse strandH4C8BTN3A2: 26,365,159–26,382,797, forward strandBTN3A2BTN2A2: 26,383,091–26,394,880, forward strandBTN2A2BTN3A1: 26,402,237–26,415,216, forward strandBTN3A1BTN3A3: 26,440,452–26,453,422, forward strandBTN3A3BTN2A1: 26,457,904–26,476,621, forward strandBTN2A1BTN1A1: 26,500,303–26,510,425, forward strandBTN1A1HMGN4: 26,538,200–26,546,949, forward strandHMGN4ABT1: 26,596,928–26,600,739, forward strandABT1Diagram of H4C3: one exon on the forward strand of chromosome 6Exon 1: 3 known disease-causing sitesExon 1: 26,103,933–26,104,337, 405 bases15′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.4 kb of the gene's 0.4 kb; 312 of those bases code for the protein.

How a genome test reads H4C3

3

positions in H4C3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 0.4 kb of H4C3, introns included, not only the 0.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). H4C3 gene: H4 clustered histone 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/h4c3

Vancouver

Dante Labs. H4C3 gene: H4 clustered histone 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/h4c3

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