Gene
RBM28
RNA binding motif protein 28
- HGNC 21863(opens in a new tab)
- Ensembl gene ENSG00000106344(opens in a new tab)
- NCBI Gene 55131(opens in a new tab)
Summary
- Cytogenetic location
- 7q32.1
- Coordinates
- Chromosome 7: 128,297,685–128,343,908 (GRCh38)
- Exons
- 19 exons across 46.2 kb
- Protein
- 759 amino acids
- Also known as
- FLJ10377, NOP4
- MANE Select transcript
- ENST00000223073.6NM_018077.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read RBM28, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated reports relevant to this gene
Hypogonadotropic Hypogonadism
Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.
- 1 GenCC submitter rates it definitive or strong
Non-Acquired Combined Pituitary Hormone Deficiency
Congenital hypopituitarism is characterized by multiple pituitary hormone deficiency, including somatotroph, thyrotroph, lactotroph, corticotroph or gonadotroph deficiencies, due to mutations of pituitary transcription factors involved in pituitary ontogenesis.
- 1 GenCC submitter rates it definitive or strong
How RBM28 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 15.5 kb of the gene's 46.2 kb; 2,280 of those bases code for the protein.
How a genome test reads RBM28
2
positions in RBM28 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 46.2 kb of RBM28, introns included, not only the 15.5 kb of exons.
Traits linked to RBM28
The Human Phenotype Ontology lists these as features of the rare conditions RBM28 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the endocrine system
- Central adrenal insufficiency
- Delayed puberty
- Hypogonadotropic hypogonadism
- Small pituitary gland
- Abnormal response to ACTH stimulation test
- Adrenocorticotropin deficient adrenal insufficiency
- Decreased circulating insulin-like growth factor 1 concentration
- Decreased response to growth hormone stimulation test
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). RBM28 gene: RNA binding motif protein 28. Retrieved 17 October 2026, from https://dantelabs.com/genes/rbm28
Dante Labs. RBM28 gene: RNA binding motif protein 28 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rbm28
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks