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Gene

CBLB

Cbl proto-oncogene B

Summary

Cytogenetic location
3q13.11
Coordinates
Chromosome 3: 105,655,461–105,869,012 (GRCh38)
Exons
19 exons across 213.6 kb
Protein
982 amino acids
Also known as
RNF56, Cbl-b
MANE Select transcript
ENST00000394030.8NM_170662.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Autoimmune Disease

    • A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).

      • 1 GenCC submitter rates it definitive or strong

How CBLB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 3, with a bracket where CBLB sits. CBLB and 1 gene near it on chromosome 3, from 105,262,237 to 106,262,236.Chromosome 33q13.11p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29105.4 Mb105.6 Mb105.8 Mb106 Mb106.2 MbALCAM: 105,366,691–105,576,909, forward strandALCAMCBLB: 105,655,461–105,869,012, reverse strandCBLBDiagram of CBLB: 19 exons on the reverse strand of chromosome 3Exon 19: 105,655,461–105,659,229, 3,769 basesExon 18: 105,670,233–105,670,352, 120 basesExon 17: 105,678,431–105,678,571, 141 basesExon 16: 105,681,479–105,681,610, 132 basesExon 15: 105,681,724–105,681,818, 95 basesExon 14: 105,685,320–105,685,466, 147 basesExon 13: 105,693,494–105,693,588, 95 basesExon 12: 105,702,094–105,702,459, 366 basesExon 11: 105,703,988–105,704,173, 186 basesExon 10: 105,720,047–105,720,250, 204 basesExon 9: 105,734,009–105,734,140, 132 basesExon 8: 105,737,171–105,737,258, 88 basesExon 7: 105,740,494–105,740,631, 138 basesExon 6: 105,745,917–105,746,038, 122 basesExon 5: 105,751,462–105,751,618, 157 basesExon 4: 105,776,396–105,776,542, 147 basesExon 3: 105,853,414–105,853,664, 251 basesExon 2: 105,867,410–105,867,591, 182 basesExon 1: 105,868,736–105,869,012, 277 bases191510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.7 kb of the gene's 213.6 kb; 2,949 of those bases code for the protein.

How a genome test reads CBLB

1

position in CBLB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 213.6 kb of CBLB, introns included, not only the 6.7 kb of exons.

Genes linked to the same conditions

Traits linked to CBLB

The Human Phenotype Ontology lists these as features of the rare conditions CBLB can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CBLB gene: Cbl proto-oncogene B. Retrieved 17 October 2026, from https://dantelabs.com/genes/cblb

Vancouver

Dante Labs. CBLB gene: Cbl proto-oncogene B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cblb

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