Trait
Pain insensitivity
Inability to perceive painful stimuli.
Summary
- Also called
- Absence of pain sensation
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Pain insensitivity, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test36 genes linked to Pain insensitivity
Changes in these genes cause rare conditions in which Pain insensitivity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATXN7L3ataxin 7 like 3 | Always | In 1 condition |
| CACNA2D1calcium voltage-gated channel auxiliary subunit alpha2delta 1 | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 1 condition |
| DSTdystonin | Always | In 1 condition |
| FLVCR1FLVCR choline and heme transporter 1 | Always | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| NGFnerve growth factor | Always | In 2 conditions |
| NGLY1N-glycanase 1 | Always | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Always | In 3 conditions |
| PRDM12PR/SET domain 12 | Always | In 1 condition |
| SCN11Asodium voltage-gated channel alpha subunit 11 | Always | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Always | In 1 condition |
| TCP1t-complex 1 | Always | In 1 condition |
| UNC13Aunc-13 homolog A | Always | In 1 condition |
| ZFHX2zinc finger homeobox 2 | Always | In 1 condition |
| ATL1atlastin GTPase 1 | Often (30–79%) | In 1 condition |
| ATL3atlastin GTPase 3 | Often (30–79%) | In 1 condition |
| CLTCL1clathrin heavy chain like 1 | Often (30–79%) | In 1 condition |
| DDHD1DDHD domain containing 1 | Often (30–79%) | In 1 condition |
| DEAF1DEAF1 transcription factor | Often (30–79%) | In 1 condition |
| EBF3EBF transcription factor 3 | Often (30–79%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Often (30–79%) | In 1 condition |
| RAI1retinoic acid induced 1 | Often (30–79%) | In 1 condition |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Often (30–79%) | In 1 condition |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Often (30–79%) | In 1 condition |
| TDP1tyrosyl-DNA phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| TRPM3transient receptor potential cation channel subfamily M member 3 | Often (30–79%) | In 1 condition |
| GRIA3glutamate ionotropic receptor AMPA type subunit 3 | Sometimes (5–29%) | In 1 condition |
| KDM5Clysine demethylase 5C | Sometimes (5–29%) | In 1 condition |
| RFX7regulatory factor X7 | Sometimes (5–29%) | In 1 condition |
| SNUPNsnurportin 1 | Sometimes (5–29%) | In 1 condition |
| TMEM218transmembrane protein 218 | Sometimes (5–29%) | In 1 condition |
| TRIOtrio Rho guanine nucleotide exchange factor | Sometimes (5–29%) | In 2 conditions |
| HDAC4histone deacetylase 4 | Not recorded | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks