Trait
Overweight
Increased body weight with a body mass index of 25-29.9 kg per square meter.
Summary
- Body system
- Growth abnormality
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test53 genes linked to Overweight
Changes in these genes cause rare conditions in which Overweight is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| OTX2orthodenticle homeobox 2 | Always | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Always | In 1 condition |
| UNC45Bunc-45 myosin chaperone B | Always | In 1 condition |
| ABCB4ATP binding cassette subfamily B member 4 | Often (30–79%) | In 1 condition |
| ADGRL1adhesion G protein-coupled receptor L1 | Often (30–79%) | In 1 condition |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Often (30–79%) | In 1 condition |
| AP4B1adaptor related protein complex 4 subunit beta 1 | Often (30–79%) | In 2 conditions |
| EHMT1euchromatic histone lysine methyltransferase 1 | Often (30–79%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 1 condition |
| PDSS1decaprenyl diphosphate synthase subunit 1 | Often (30–79%) | In 1 condition |
| SLC9A7solute carrier family 9 member A7 | Often (30–79%) | In 1 condition |
| TAOK1TAO kinase 1 | Often (30–79%) | In 1 condition |
| THOC2THO complex subunit 2 | Often (30–79%) | In 1 condition |
| TMEM218transmembrane protein 218 | Often (30–79%) | In 1 condition |
| TRHRthyrotropin releasing hormone receptor | Often (30–79%) | In 1 condition |
| ZBTB7Azinc finger and BTB domain containing 7A | Often (30–79%) | In 1 condition |
| ABCC8ATP binding cassette subfamily C member 8 | Sometimes (5–29%) | In 1 condition |
| ACADVLacyl-CoA dehydrogenase very long chain | Sometimes (5–29%) | In 1 condition |
| AP4E1adaptor related protein complex 4 subunit epsilon 1 | Sometimes (5–29%) | In 2 conditions |
| AP4M1adaptor related protein complex 4 subunit mu 1 | Sometimes (5–29%) | In 1 condition |
| AP4S1adaptor related protein complex 4 subunit sigma 1 | Sometimes (5–29%) | In 1 condition |
| APPL1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 | Sometimes (5–29%) | In 1 condition |
| ASH1LASH1 like histone lysine methyltransferase | Sometimes (5–29%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Sometimes (5–29%) | In 2 conditions |
| CELcarboxyl ester lipase | Sometimes (5–29%) | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Sometimes (5–29%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Sometimes (5–29%) | In 1 condition |
| CTSKcathepsin K | Sometimes (5–29%) | In 1 condition |
| FOXP1forkhead box P1 | Sometimes (5–29%) | In 1 condition |
| GCKglucokinase | Sometimes (5–29%) | In 1 condition |
| HESX1HESX homeobox 1 | Sometimes (5–29%) | In 1 condition |
| HNF1AHNF1 homeobox A | Sometimes (5–29%) | In 1 condition |
| HNF4Ahepatocyte nuclear factor 4 alpha | Sometimes (5–29%) | In 1 condition |
| INSinsulin | Sometimes (5–29%) | In 1 condition |
| KCNJ11potassium inwardly rectifying channel subfamily J member 11 | Sometimes (5–29%) | In 1 condition |
| KLF11KLF transcription factor 11 | Sometimes (5–29%) | In 1 condition |
| LHX3LIM homeobox 3 | Sometimes (5–29%) | In 1 condition |
| LHX4LIM homeobox 4 | Sometimes (5–29%) | In 1 condition |
Show 13 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MYT1Lmyelin transcription factor 1 like | Sometimes (5–29%) | In 1 condition |
| NEUROD1neuronal differentiation 1 | Sometimes (5–29%) | In 1 condition |
| PAX4paired box 4 | Sometimes (5–29%) | In 1 condition |
| PDX1pancreatic and duodenal homeobox 1 | Sometimes (5–29%) | In 1 condition |
| POU1F1POU class 1 homeobox 1 | Sometimes (5–29%) | In 1 condition |
| PROP1PROP paired-like homeobox 1 | Sometimes (5–29%) | In 1 condition |
| SATB1SATB homeobox 1 | Sometimes (5–29%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Sometimes (5–29%) | In 1 condition |
| TRIP4thyroid hormone receptor interactor 4 | Sometimes (5–29%) | In 1 condition |
| USP7ubiquitin specific peptidase 7 | Sometimes (5–29%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| CFAP418cilia and flagella associated protein 418 | Not recorded | In 1 condition |
| IGSF1immunoglobulin superfamily member 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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