Trait
Cogwheel rigidity
A type of rigidity in which a muscle responds with cogwheellike jerks to the use of constant force in bending the limb (i.e., it gives way in little, repeated jerks when the muscle is passively stretched).
Summary
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Get my Genome Test35 genes linked to Cogwheel rigidity
Changes in these genes cause rare conditions in which Cogwheel rigidity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP6AP2ATPase H+ transporting accessory protein 2 | Always | In 2 conditions |
| KCNA4potassium voltage-gated channel subfamily A member 4 | Always | In 1 condition |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| PTRHD1peptidyl-tRNA hydrolase domain containing 1 | Always | In 1 condition |
| DAB1DAB adaptor protein 1 | Very often (80–99%) | In 1 condition |
| RAB39BRAB39B, member RAS oncogene family | Very often (80–99%) | In 2 conditions |
| SLC19A3solute carrier family 19 member 3 | Very often (80–99%) | In 1 condition |
| GABRA1gamma-aminobutyric acid type A receptor subunit alpha1 | Often (30–79%) | In 1 condition |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Often (30–79%) | In 1 condition |
| MMEmembrane metalloendopeptidase | Often (30–79%) | In 1 condition |
| PCDH19protocadherin 19 | Often (30–79%) | In 1 condition |
| PRKNparkin RBR E3 ubiquitin protein ligase | Often (30–79%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Often (30–79%) | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Often (30–79%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Often (30–79%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Often (30–79%) | In 1 condition |
| SLC6A3solute carrier family 6 member 3 | Often (30–79%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| FRRS1Lferric chelate reductase 1 like | Sometimes (5–29%) | In 1 condition |
| GCH1GTP cyclohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| KCND3potassium voltage-gated channel subfamily D member 3 | Sometimes (5–29%) | In 2 conditions |
| KCNN2potassium calcium-activated channel subfamily N member 2 | Sometimes (5–29%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Sometimes (5–29%) | In 1 condition |
| NUP54nucleoporin 54 | Sometimes (5–29%) | In 1 condition |
| NUP62nucleoporin 62 | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 2 conditions |
| POLG2DNA polymerase gamma 2, accessory subunit | Sometimes (5–29%) | In 1 condition |
| RRM1ribonucleotide reductase catalytic subunit M1 | Sometimes (5–29%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Sometimes (5–29%) | In 1 condition |
| TK2thymidine kinase 2 | Sometimes (5–29%) | In 1 condition |
| TOP3ADNA topoisomerase III alpha | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 1 condition |
| CPceruloplasmin | Not recorded | In 1 condition |
| TMEM240transmembrane protein 240 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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