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Trait

Food allergy

Primary food allergies primarily occur as a result (most likely) of gastrointestinal sensitization to predominantly stable food allergens (glycoproteins). A secondary food allergy develops after primary sensitization to airborne allergens (e. g., pollen allergens) with subsequent reactions (due to cross-reactivity) to structurally related often labile allergens in (plant) foods.

HPO HP:0500093

Summary

Also called
Allergic reaction to foods, IgE-mediated food allergy, Immunoglobulin E-mediated food allergy, Reaction to food allergens
Body system
Abnormality of the immune system

21 genes linked to Food allergy

Changes in these genes cause rare conditions in which Food allergy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
DSG1desmoglein 1AlwaysIn 1 condition
IL6STinterleukin 6 cytokine family signal transducerAlwaysIn 2 conditions
JAK1Janus kinase 1AlwaysIn 1 condition
LRRC7leucine rich repeat containing 7AlwaysIn 1 condition
POLD3DNA polymerase delta 3, accessory subunitAlwaysIn 1 condition
DOCK8dedicator of cytokinesis 8Very often (80–99%)In 1 condition
SPINK5serine peptidase inhibitor Kazal type 5Very often (80–99%)In 2 conditions
STAT6signal transducer and activator of transcription 6Very often (80–99%)In 1 condition
ABCC9ATP binding cassette subfamily C member 9Often (30–79%)In 1 condition
CARD11caspase recruitment domain family member 11Often (30–79%)In 1 condition
FOXP3forkhead box P3Often (30–79%)In 1 condition
ITGAVintegrin subunit alpha VOften (30–79%)In 1 condition
PGM3phosphoglucomutase 3Often (30–79%)In 1 condition
SLC19A1solute carrier family 19 member 1Often (30–79%)In 1 condition
CAMK2Bcalcium/calmodulin dependent protein kinase II betaSometimes (5–29%)In 1 condition
PORCNporcupine O-acyltransferaseSometimes (5–29%)In 1 condition
SLC27A4solute carrier family 27 member 4Sometimes (5–29%)In 1 condition
SOX6SRY-box transcription factor 6Sometimes (5–29%)In 1 condition
IGHG2immunoglobulin heavy constant gamma 2 (G2m marker)Rarely (1–4%)In 1 condition
IGKCimmunoglobulin kappa constantRarely (1–4%)In 1 condition
SPTBN1spectrin beta, non-erythrocytic 1Rarely (1–4%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Allergy

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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