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Gene

CTH

cystathionine gamma-lyase

Summary

Cytogenetic location
1p31.1
Coordinates
Chromosome 1: 70,411,268–70,439,851 (GRCh38)
Exons
12 exons across 28.6 kb
Protein
405 amino acids
Also known as
CSE
MANE Select transcript
ENST00000370938.8NM_001902.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CTH yet. The test sequences your whole genome, so your data includes it all the same.

How CTH is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where CTH sits. CTH and 5 genes near it on chromosome 1, from 69,925,560 to 70,925,559.Chromosome 11p31.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4470 Mb70.2 Mb70.4 Mb70.6 Mb70.8 MbLRRC7: 69,567,871–70,151,945, forward strandLRRC7LRRC40: 70,143,215–70,205,665, reverse strandLRRC40SRSF11: 70,205,670–70,253,052, forward strandSRSF11ANKRD13C: 70,258,999–70,354,747, reverse strandANKRD13CCTH: 70,411,268–70,439,851, forward strandCTHPTGER3: 70,852,305–71,047,823, reverse strandPTGER3Diagram of CTH: 12 exons on the forward strand of chromosome 1Exon 8: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 1: 70,411,268–70,411,583, 316 basesExon 2: 70,415,956–70,416,037, 82 basesExon 3: 70,417,937–70,418,032, 96 basesExon 4: 70,421,566–70,421,675, 110 basesExon 5: 70,424,285–70,424,416, 132 basesExon 6: 70,429,794–70,429,851, 58 basesExon 7: 70,430,317–70,430,394, 78 basesExon 8: 70,432,083–70,432,235, 153 basesExon 9: 70,433,828–70,433,949, 122 basesExon 10: 70,435,125–70,435,177, 53 basesExon 11: 70,438,688–70,438,826, 139 basesExon 12: 70,439,101–70,439,851, 751 bases1234567891011125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 28.6 kb; 1,218 of those bases code for the protein.

How a genome test reads CTH

2

positions in CTH where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 28.6 kb of CTH, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CTH gene: cystathionine gamma-lyase. Retrieved 17 October 2026, from https://dantelabs.com/genes/cth

Vancouver

Dante Labs. CTH gene: cystathionine gamma-lyase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cth

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