Traits

Traits linked to GPR101

G protein-coupled receptor 101

The Human Phenotype Ontology links 104 traits to GPR101, by body system: features seen in people with one of the gene's rare conditions.

GPR101

Abnormality of head or neck

Trait	How often it is seen
Abnormally large tongue	Very often (80–99%)
Big lower jaw	Very often (80–99%)
Broad forehead	Very often (80–99%)
Coarse facial features	Very often (80–99%)
Full cheeks	Very often (80–99%)
Long face	Very often (80–99%)
Wide nose	Very often (80–99%)
Abnormal dentition	Often (30–79%)
Broad jaw	Often (30–79%)
Facial shape deformation	Often (30–79%)
Frontal bossing	Often (30–79%)
Full lips	Often (30–79%)
Fullness of eyelids	Often (30–79%)
Monobrow	Often (30–79%)
Prominent brow	Often (30–79%)
Widely spaced teeth	Often (30–79%)
Bad bite	Sometimes (5–29%)
Furrows in thickened skin on top of scalp	Sometimes (5–29%)

Abnormality of the endocrine system

Trait	How often it is seen
Growth hormone excess	Always
Hypopituitarism	Always
Increased circulating insulin-like growth factor 1 concentration	Always
Abnormality of the endocrine system	Very often (80–99%)
Anterior hypopituitarism	Very often (80–99%)
Increased circulating prolactin concentration	Very often (80–99%)
Noncancerous tumor in pituitary gland	Very often (80–99%)
Pituitary growth hormone cell adenoma	Very often (80–99%)
Hypogonadotropic hypogonadism	Often (30–79%)
Multinodular goiter	Often (30–79%)
Pituitary macroadenoma	Often (30–79%)
Adrenal insufficiency	Sometimes (5–29%)
Low thyroid gland function due to abnormal pituitary gland	Sometimes (5–29%)
Pituitary prolactin cell adenoma	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Epilepsy	Always
Anxiety	Often (30–79%)
Constrictive median neuropathy	Often (30–79%)
Depression	Often (30–79%)
Headache	Often (30–79%)
Migraine	Often (30–79%)
Pauses in breathing while sleeping	Often (30–79%)
Pins and needles feeling	Often (30–79%)
Cranial nerve paralysis	Sometimes (5–29%)
Excessive daytime sleepiness	Sometimes (5–29%)
Too much cerebrospinal fluid in the brain	Sometimes (5–29%)
Willis-Ekbom disease	Sometimes (5–29%)
Increased appetite	Not recorded
Snoring	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormality of the menstrual cycle	Often (30–79%)
Painful menstruation	Often (30–79%)
Decreased libido	Sometimes (5–29%)
Difficulty getting a full erection	Sometimes (5–29%)
Dull burning sensation with urination	Sometimes (5–29%)
Infertility	Sometimes (5–29%)
Light or infrequent menstrual periods	Sometimes (5–29%)
Previous menstrual periods stop	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Broad foot	Very often (80–99%)
Cortical diaphyseal thickening of the upper limbs	Very often (80–99%)
Deep palm line	Very often (80–99%)
Deep wrinkles in soles of feet	Very often (80–99%)
Finger overgrowth	Very often (80–99%)
Large hands	Very often (80–99%)
Tapered finger	Very often (80–99%)

Abnormality of the integument

Trait	How often it is seen
Excessive sweating	Very often (80–99%)
Thickened skin	Very often (80–99%)
Excessive hairiness over body	Often (30–79%)
Skin tags	Often (30–79%)
Darkened and thickened skin	Sometimes (5–29%)
Excessive hair growth	Sometimes (5–29%)
Generalized hyperpigmentation	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)
Abnormal heart rate	Sometimes (5–29%)
Abnormal heart valve physiology	Sometimes (5–29%)
Enlarged and thickened heart muscle	Sometimes (5–29%)
Mitral regurgitation	Sometimes (5–29%)
Ventricular hypertrophy	Not recorded

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)
Joint pain	Very often (80–99%)
Lack of energy and strength	Often (30–79%)
Muscle ache	Sometimes (5–29%)
Night sweats	Sometimes (5–29%)
Body odor	Not recorded

Laboratory abnormality

Trait	How often it is seen
Joint swelling	Very often (80–99%)
Body fails to respond to insulin	Often (30–79%)
Diabetes mellitus	Often (30–79%)
Noninsulin-dependent diabetes	Often (30–79%)
Decreased circulating high-density lipoprotein cholesterol	Sometimes (5–29%)
Increased plasma triglycerides	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Hunched back	Always
Degenerative joint disease	Very often (80–99%)
Narrow spinal canal	Often (30–79%)
Compression fracture of a vertebral body	Sometimes (5–29%)
Advanced bone age	Not recorded

Abnormality of the eye

Trait	How often it is seen
Hemianopia	Always
Eye muscle paralysis	Sometimes (5–29%)
Partial loss of field of vision	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
General overgrowth	Always
Acral overgrowth	Very often (80–99%)
Tall stature	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Gallstones	Sometimes (5–29%)
Intestinal polyp	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Seborrheic dermatitis	Very often (80–99%)
Acne	Sometimes (5–29%)

Abnormality of the breast

Trait	How often it is seen
Spontaneous milk flow from breast	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Large ears	Very often (80–99%)

Abnormality of the voice

Trait	How often it is seen
Hoarse voice	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GPR101 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test