Trait

Ventricular hypertrophy

Enlargement of the cardiac ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy.

HPO HP:0001714

Body system: Abnormality of the cardiovascular system

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29 genes linked to Ventricular hypertrophy

Changes in these genes cause rare conditions in which Ventricular hypertrophy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
COX6B1cytochrome c oxidase subunit 6B1	Always	In 1 condition
DNM1Ldynamin 1L	Always	In 1 condition
PTBP1polypyrimidine tract binding protein 1	Always	In 1 condition
SCO1synthesis of cytochrome C oxidase 1	Always	In 1 condition
CACNA1Dcalcium voltage-gated channel subunit alpha1 D	Very often (80–99%)	In 1 condition
LMNAlamin A/C	Very often (80–99%)	In 2 conditions
GYG1glycogenin 1	Often (30–79%)	In 1 condition
MYBPC3myosin binding protein C3	Often (30–79%)	In 1 condition
SMAD2SMAD family member 2	Often (30–79%)	In 1 condition
ABCC6ATP binding cassette subfamily C member 6	Sometimes (5–29%)	In 1 condition
COX7Bcytochrome c oxidase subunit 7B	Sometimes (5–29%)	In 1 condition
CPT2carnitine palmitoyltransferase 2	Sometimes (5–29%)	In 1 condition
ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1	Sometimes (5–29%)	In 1 condition
GBA1glucosylceramidase beta 1	Sometimes (5–29%)	In 1 condition
RAP1BRAP1B, member of RAS oncogene family	Sometimes (5–29%)	In 1 condition
SMAD3SMAD family member 3	Sometimes (5–29%)	In 1 condition
WACWW domain containing adaptor with coiled-coil	Sometimes (5–29%)	In 1 condition
ZMPSTE24zinc metallopeptidase STE24	Sometimes (5–29%)	In 1 condition
AGLamylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase	Not recorded	In 1 condition
CHST3carbohydrate sulfotransferase 3	Not recorded	In 1 condition
FHL1four and a half LIM domains 1	Not recorded	In 1 condition
GPR101G protein-coupled receptor 101	Not recorded	In 1 condition
NOD2nucleotide binding oligomerization domain containing 2	Not recorded	In 1 condition
NSMCE2NSE2 SUMO ligase component of SMC5/6 complex	Not recorded	In 1 condition
RPL5ribosomal protein L5	Not recorded	In 1 condition
SGCDsarcoglycan delta	Not recorded	In 1 condition
SLC25A20solute carrier family 25 member 20	Not recorded	In 1 condition
SLC2A10solute carrier family 2 member 10	Not recorded	In 1 condition
TNNI3troponin I3, cardiac type	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal cardiac ventricle morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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