Skip to content
Use your HSA or FSA funds

Gene

MNX1

motor neuron and pancreas homeobox 1

Summary

Cytogenetic location
7q36.3
Coordinates
Chromosome 7: 157,004,854–157,010,663 (GRCh38)
Exons
3 exons across 5.8 kb
Protein
401 amino acids
Also known as
HB9, HOXHB9, SCRA1
Previous symbols
HLXB9
MANE Select transcript
ENST00000252971.11NM_005515.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Diabetes Mellitus

    • A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Teplizumab (Tzield) for stage 2 presymptomatic T1D (FDA approved 2022); insulin replacement at clinical T1D onset; TrialNet autoantibody screening for high-risk relatives; closed-loop insulin delivery systems

  • Neonatal Diabetes Mellitus

    • Diabetes diagnosed in the first months of life, either permanent or transient, caused by single-gene defects in insulin production or secretion.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Most people with KCNJ11 or ABCC8 neonatal diabetes can switch from insulin injections to sulfonylurea tablets, often with better glucose control.

How MNX1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 7, with a bracket where MNX1 sits. MNX1 and 5 genes near it on chromosome 7, from 156,507,759 to 157,507,758.Chromosome 77q36.3p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3156.6 Mb156.8 Mb157 Mb157.2 Mb157.4 MbRNF32: 156,640,281–156,677,780, forward strandRNF32LMBR1: 156,668,946–156,893,225, reverse strandLMBR1NOM1: 156,949,706–156,973,176, forward strandNOM1MNX1: 157,004,854–157,010,663, reverse strandMNX1UBE3C: 157,138,908–157,269,372, forward strandUBE3CDNAJB6: 157,335,381–157,432,974, forward strandDNAJB6Diagram of MNX1: 3 exons on the reverse strand of chromosome 7Exon 3: 2 known disease-causing sitesExon 1: 9 known disease-causing sitesExon 3: 157,004,854–157,005,873, 1,020 basesExon 2: 157,006,479–157,006,639, 161 basesExon 1: 157,009,660–157,010,663, 1,004 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 5.8 kb; 1,206 of those bases code for the protein.

How a genome test reads MNX1

12

positions in MNX1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.8 kb of MNX1, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MNX1 gene: motor neuron and pancreas homeobox 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/mnx1

Vancouver

Dante Labs. MNX1 gene: motor neuron and pancreas homeobox 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mnx1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test