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Gene

RNF170

ring finger protein 170

Summary

Cytogenetic location
8p11.21
Coordinates
Chromosome 8: 42,853,301–42,896,605 (GRCh38)
Exons
7 exons across 43.3 kb
Protein
258 amino acids
Also known as
DKFZP564A022, ADSA
Previous symbols
SNAX1
MANE Select transcript
ENST00000527424.6NM_030954.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hereditary Spastic Paraplegia

      • Hereditary Spastic Paraplegia (All Types)

        One of 66 genes linked to it

        Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

        • 2 GenCC submitters rate it definitive or strong

    How RNF170 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 8, with a bracket where RNF170 sits. RNF170 and 13 genes near it on chromosome 8, from 42,374,953 to 43,374,952.Chromosome 88p11.21p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.342.4 Mb42.6 Mb42.8 Mb43 Mb43.2 MbDKK4: 42,373,195–42,384,830, reverse strandDKK4VDAC3: 42,391,624–42,407,493, forward strandVDAC3SLC20A2: 42,416,449–42,542,530, reverse strandSLC20A2SMIM19: 42,541,132–42,555,195, forward strandSMIM19CHRNB3: 42,697,341–42,738,553, forward strandCHRNB3CHRNA6: 42,752,620–42,796,392, reverse strandCHRNA6THAP1: 42,836,249–42,843,364, reverse strandTHAP1RNF170: 42,853,301–42,896,605, reverse strandRNF170HOOK3: 42,896,499–43,030,535, forward strandHOOK3: 43,018,424–43,077,334, forward strandFNTA: 43,034,194–43,085,793, forward strandFNTAPOMK: 43,093,498–43,132,733, forward strandPOMKHGSNAT: 43,140,374–43,202,855, forward strandHGSNATPOTEA: 43,292,483–43,363,518, forward strandPOTEADiagram of RNF170: 7 exons on the reverse strand of chromosome 8Exon 7: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 7: 42,853,301–42,856,428, 3,128 basesExon 6: 42,861,745–42,861,855, 111 basesExon 5: 42,865,416–42,865,489, 74 basesExon 4: 42,870,004–42,870,112, 109 basesExon 3: 42,873,931–42,874,006, 76 basesExon 2: 42,887,728–42,887,871, 144 basesExon 1: 42,896,484–42,896,605, 122 bases76543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.8 kb of the gene's 43.3 kb; 777 of those bases code for the protein.

    How a genome test reads RNF170

    8

    positions in RNF170 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 43.3 kb of RNF170, introns included, not only the 3.8 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). RNF170 gene: ring finger protein 170. Retrieved 16 October 2026, from https://dantelabs.com/genes/rnf170

    Vancouver

    Dante Labs. RNF170 gene: ring finger protein 170 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rnf170

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