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Gene

KCND3

potassium voltage-gated channel subfamily D member 3

Summary

Cytogenetic location
1p13.2
Coordinates
Chromosome 1: 111,770,662–111,989,668 (GRCh38)
Exons
8 exons across 219 kb
Protein
655 amino acids
Inheritance
Autosomal dominant
Also known as
Kv4.3, KSHIVB
Previous symbols
SCA22, SCA19
MANE Select transcript
ENST00000302127.5NM_001378969.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Autosomal Dominant Cerebellar Ataxias (SCAs and DRPLA)

    • Autosomal Dominant Cerebellar AtaxiaAutosomal dominant

      A group of dominantly inherited ataxias, including SCA1, SCA2, SCA3 (Machado-Joseph disease), SCA6, SCA7, SCA17, SCA27B and DRPLA, caused by repeat expansions or point variants in genes such as ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and FGF14.

      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Genetic counselling and presymptomatic testing for relatives, physiotherapy and symptom management; some forms, such as SCA27B, may respond to specific medication.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How KCND3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where KCND3 sits. KCND3 and 9 genes near it on chromosome 1, from 111,380,165 to 112,380,164.Chromosome 11p13.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44111.4 Mb111.6 Mb111.8 Mb112 Mb112.2 MbOVGP1: 111,413,379–111,427,735, reverse strandOVGP1WDR77: 111,437,222–111,449,297, reverse strandWDR77ATP5PB: 111,448,111–111,468,527, forward strandATP5PBC1orf162: 111,473,754–111,478,513, forward strandC1orf162TMIGD3: 111,480,668–111,563,962, reverse strandTMIGD3ADORA3: 111,499,429–111,503,854, reverse strandADORA3RAP1A: 111,542,009–111,716,691, forward strandRAP1AINKA2: 111,680,223–111,755,824, reverse strandINKA2DDX20: 111,754,832–111,775,602, forward strandDDX20KCND3: 111,770,662–111,989,668, reverse strandKCND3Diagram of KCND3: 8 exons on the reverse strand of chromosome 1Exon 4: 1 known disease-causing siteExon 3: 7 known disease-causing sitesExon 2: 12 known disease-causing sitesExon 8: 111,770,662–111,776,278, 5,617 basesExon 7: 111,777,026–111,777,273, 248 basesExon 6: 111,778,436–111,778,492, 57 basesExon 5: 111,780,225–111,780,314, 90 basesExon 4: 111,780,690–111,780,791, 102 basesExon 3: 111,786,944–111,787,106, 163 basesExon 2: 111,981,621–111,982,798, 1,178 basesExon 1: 111,989,505–111,989,668, 164 bases8515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.6 kb of the gene's 219 kb; 1,968 of those bases code for the protein.

How a genome test reads KCND3

20

positions in KCND3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 219 kb of KCND3, introns included, not only the 7.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KCND3 gene: potassium voltage-gated channel subfamily D member 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/kcnd3

Vancouver

Dante Labs. KCND3 gene: potassium voltage-gated channel subfamily D member 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/kcnd3

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